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POLB - DNA polymerase beta Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5423

About POLB

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,338,494-42,371,808 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and 3 paralogues. Broad expression in testis (RPKM 24.2), urinary bladder (RPKM 8.5) and 24 other tissues.

Summary

The protein encoded by this gene is a DNA Polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]

POLB Products (1)

mRNA	Protein	Name
NM_002690.3	NP_002681.1	DNA polymerase beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5'-deoxyribose-5-phosphate lyase activity	IDA IDA: Inferred from direct assay	9614142	GOA
enables DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	9207062	GOA
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: Inferred from direct assay	9614142	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16600869	GOA
enables lyase activity	IDA IDA: Inferred from direct assay	16600869	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	15725623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9207062	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	21362556	GOA
involved in base-excision repair	IDA IDA: Inferred from direct assay	16600869	GOA
involved in base-excision repair	IMP IMP: Inferred from mutant phenotype	21362556	GOA
NOT involved in nucleotide-excision repair, DNA gap filling	IMP IMP: Inferred from mutant phenotype	20227374	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15725623	GOA
located in microtubule	IDA IDA: Inferred from direct assay	15725623	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19713937	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25378300	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	15725623	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLB Protein Structure

HHH_8

DNA_pol_lambd_f

DNA_pol_B_palm

DNA_pol_B_thumb

0
100
200
300
335 a.a.

Protein Preferred Names	Protein Names
DNA polymerase beta	DNA pol beta

POLB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Validated Y2H	25910212
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Array	31515488
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Bait-Prey Pool	25910212
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Array	25910212
Intra	POLB	P06746	TPP2	Homo sapiens	P29144	Validated Y2H	25416956
Intra	POLB	P06746	TAF1D	Homo sapiens	Q9H5J8	Anti Tag CoIP	15520167
Intra	POLB	P06746	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	33961781
Intra	POLB	P06746	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant POLB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7883	DNA polymerase beta Protein, Human (His)	P06746 (S2-E335)	≥ 95%, as determined by reducing SDS-PAGE.

POLB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83633	DNA Polymerase beta Antibody (YA3378)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Rhabdomyosarcoma
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10818	POLB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10830	POLG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19369	Polb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25861	Polb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POLB	RGD	RGD:3363
Mus musculus	POLB	MGD	MGI:97740
Felis catus	POLB	VGNC	VGNC:68935
Macaca mulatta	POLB	VGNC	VGNC:104470
Canis familiaris	POLB	VGNC	VGNC:44773
Bos taurus	POLB	VGNC	VGNC:33112
Others	POLB	NCBI