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Npy1r - neuropeptide Y receptor Y1 Gene

Also Known as NPY-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29358

About Npy1r

Primary_assembly 16: 23,037,789-23,046,759 reverse strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 145 orthologues, 50 paralogues and is associated with 19 phenotypes. Biased expression in Brain (RPKM 32.2), Adrenal (RPKM 2.1) and 8 other tissues.

Summary

Predicted to enable pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; peristalsis; and positive regulation of vasoconstriction. Located in several cellular components, including axon; cytosol; and synaptic vesicle. Used to study anxiety disorder; childhood absence epilepsy; hypertension; and mental depression. Biomarker of obesity and visual epilepsy. Orthologous to human NPY1R (Neuropeptide Y Receptor Y1). [provided by Alliance of Genome Resources, Apr 2022]

Npy1r Products (1)

mRNA	Protein	Name
NM_001113357.1	NP_001106828.1	neuropeptide Y receptor type 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	17143304	RGD
involved in negative regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	10464394	RGD
involved in peristalsis	IMP IMP: Inferred from mutant phenotype	12919938	RGD
involved in positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	32976883	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	9802404	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	EXP EXP: Inferred from Experiment	16026936	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	16026936	RGD
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	16026936	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	16026936	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	16904299	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	14726443	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	19267419	RGD
involved in response to morphine	IMP IMP: Inferred from mutant phenotype	16766046	RGD
involved in synaptic signaling via neuropeptide	EXP EXP: Inferred from Experiment	11677256	RGD
involved in synaptic signaling via neuropeptide	IDA IDA: Inferred from direct assay	11677256	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	11891789	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	11677256	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11677256	RGD
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	29775703	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	11891789	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	11891789	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Npy1r Protein Structure

7tmA_NPY1R

0
100
200
300
382 a.a.

Protein Preferred Names	Protein Names
neuropeptide Y receptor type 1	FC5 NPY1-R Neuropepetide Y1 Receptor neuropeptide Y1 receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS09512	Npy1r Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS09511	NPY1R Human Pre-designed siRNA Set A	/	Unkown
HY-RS09513	Npy1r Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npy1r	NCBI	NCBI:4886