NPY1R - neuropeptide Y receptor Y1 Gene

Also Known as NPYR; NPY1-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4886

About NPY1R

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,323,962-163,344,689 (from NCBI)

This gene has 7 transcripts (splice variants), 145 orthologues and 33 paralogues. Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues.

Summary

This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of Adenylate Cyclase activity. [provided by RefSeq, Aug 2013]

NPY1R Products (3)

mRNA Protein Name
NM_000909.6 NP_000900.1 neuropeptide Y receptor type 1
XM_005263031.5 XP_005263088.1 neuropeptide Y receptor type 1 isoform X1
XM_011532010.4 XP_011530312.1 neuropeptide Y receptor type 1 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23597562 GOA
Biological Process GO Annotation Evidence References Source
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPY1R Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 320)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 1

NPY1R Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NPY1R P25929 PYY Homo sapiens P10082
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pelvic Organ Prolapse

  • Rectal Prolapse

  • Pelvic Organ Prolapse, Susceptibility To

  • Pelvic Organ Prolapse, Susceptibility To, 1

  • Prolapse Of Vagina And Rectum

  • Vaginal Prolapse

  • Pelvic Organ Prolapse 1

  • Procidentia, Rectum

  • Prolapse Of Rectal Mucosa

  • Procidentia Of Rectum

  • Rectal Mucosa Prolapse

  • Rectum Prolapse

  • Procidentia Rectum

  • Rp - [Rectal Prolapse]

  • Male Proctocele

  • Male Rectocele

  • Proctoptosis

  • Female Genital Prolapse

  • Female Prolapse

  • Incompetence Of Pelvic Fundus

  • Relaxation Of Perineum

  • Deficiency Of Perineum
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09512 Npy1r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09511 NPY1R Human Pre-designed siRNA Set A / Unkown
HY-RS09513 Npy1r Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NPY1R VGNC VGNC:75394
Felis catus NPY1R VGNC VGNC:78537
Rattus norvegicus NPY1R RGD RGD:3198
Mus musculus NPY1R MGD MGI:104963
Bos taurus NPY1R VGNC VGNC:32223
Canis familiaris NPY1R VGNC VGNC:43937
Others NPY1R NCBI