Kcnq4 - potassium voltage-gated channel subfamily Q member 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298496

Summary

Enables Potassium Channel activity. Involved in negative regulation of dopaminergic synaptic transmission; potassium ion transport; and sensory perception of sound. Located in cytoplasm; neuron projection; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2A and sensorineural hearing loss. Orthologous to human KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq4 Products (6)

mRNA Protein Name
XM_039111224.1 XP_038967152.1 potassium voltage-gated channel subfamily KQT member 4 isoform X2
XM_008764110.3 XP_008762332.1 potassium voltage-gated channel subfamily KQT member 4 isoform X4
XM_039111225.1 XP_038967153.1 potassium voltage-gated channel subfamily KQT member 4 isoform X3
XM_008764109.2 XP_008762331.1 potassium voltage-gated channel subfamily KQT member 4 isoform X1
XM_008764111.3 XP_008762333.1 potassium voltage-gated channel subfamily KQT member 4 isoform X5
XM_039111226.1 XP_038967154.1 potassium voltage-gated channel subfamily KQT member 4 isoform X6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables potassium channel activity IDA
IDA: Inferred from direct assay
17021181 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
16775195 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
17021181 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily KQT member 4

  • KQT-like 4

  • potassium channel subunit alpha KvLQT4

  • potassium channel, voltage-gated KQT-like subfamily Q, member 4

  • potassium voltage-gated channel, KQT-like subfamily, member 4

  • voltage-gated potassium channel subunit Kv7.4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122114 ICA-27243 Activator 98.74% Unkown
HY-18063 ML252 Inhibitor 99.9% Unkown
HY-123264 RL648_81 Inhibitor 99.49% Unkown
HY-18063A ML252 hydrochloride Inhibitor 98.5% Unkown
HY-182435 CLE-030 Agonist / Unkown
HY-RS07176 KCNQ4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-115823 ztz240 99.94% Unkown
HY-RS18392 Kcnq4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24873 Kcnq4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnq4 NCBI NCBI:9132