GZMH - granzyme H Gene

Also Known as CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2999

About GZMH

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,606,480-24,609,685 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 6 paralogues. Broad expression in spleen (RPKM 9.5), bone marrow (RPKM 8.3) and 21 other tissues.

Summary

This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]

GZMH Products (3)

mRNA Protein Name
NM_001270780.2 NP_001257709.1 granzyme H isoform 2 precursor
NM_001270781.2 NP_001257710.1 granzyme H isoform 3 precursor
NM_033423.5 NP_219491.1 granzyme H isoform 1 preproprotein

GZMH Protein Structure

Trypsin

Trypsin: Trypsin (21 - 239)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

granzyme H

  • cathepsin G-like 2, protein h-CCPX

Recombinant GZMH Proteins

Cat. No. Product Name Accession Purity
HY-P74115 Granzyme H/GZMH Protein, Human (HEK293, His) NP_219491.1 (E19-L246) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lipodystrophy, Congenital Generalized, Type 2

  • Congenital Generalized Lipodystrophy Type 2

  • CGL2

  • Berardinelli-Seip Congenital Lipodystrophy Type 2

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome Bscl2-Related

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Berardinelli-Seip Congenital Lipodystrophy, Type 2

  • Seip Syndrome

  • Berardinelli Syndrome

  • Lipodystrophy, Total, And Acromegaloid Gigantism

  • Lipoatrophic Diabetes, Congenital

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 2

  • Brunzell Syndrome, Bscl2-Related

  • Congenital Lipoatrophic Diabetes

  • Congenital Generalized Lipodystrophy 2

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05941 GZMH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GZMH VGNC VGNC:73338
Rattus norvegicus GZMH RGD RGD:628603
Others GZMH NCBI