PLA2G2E - phospholipase A2 group IIE Gene

Also Known as sPLA2-IIE; GIIE sPLA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30814

About PLA2G2E

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,920,009-19,923,617 (from NCBI)

This gene has 1 transcript (splice variant), 139 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

Enables calcium ion binding activity and calcium-dependent Phospholipase A2 activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within low-density lipoprotein particle remodeling. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PLA2G2E Products (1)

mRNA Protein Name
NM_014589.3 NP_055404.1 group IIE secretory phospholipase A2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
28883454 GOA
enables calcium-dependent phospholipase A2 activity IDA
IDA: Inferred from direct assay
28883454 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G2E Protein Structure

Phospholip_A2_1

Phospholip_A2_1: Phospholipase A2 (20 - 131)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

group IIE secretory phospholipase A2

  • phosphatidylcholine 2-acylhydrolase 2E

Related Diseases

Diseases Alias
Benign Secondary Hypertension
Benign Renovascular Hypertension
Inflammatory Bowel Disease 6

  • IBD6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10623 PLA2G2E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18318 Pla2g2e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24796 Pla2g2e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLA2G2E VGNC VGNC:32957
Mus musculus PLA2G2E MGD MGI:1349660
Canis familiaris PLA2G2E VGNC VGNC:103648
Macaca mulatta PLA2G2E VGNC VGNC:106473
Rattus norvegicus PLA2G2E RGD RGD:1309611
Others PLA2G2E NCBI