2. Gene
  3. HLA-DOA - major histocompatibility complex, class II, DO alpha Gene

HLA-DOA - major histocompatibility complex, class II, DO alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HLADZ; HLA-DNA; HLA-DZA

Gene ID: 3111 | Gene type: protein coding

About HLA-DOA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,004,182-33,009,591 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 89 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 26.6), spleen (RPKM 26.2) and 20 other tissues.

Summary

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

HLA-DOA Products(1)

mRNA Protein Name
NM_002119.4 NP_002110.1 HLA class II histocompatibility antigen, DO alpha chain precursor

HLA-DOA Protein Structure

MHC_II_alpha

MHC_II_alpha: Class II histocompatibility antigen, alpha domain (29 - 110)

C1-set

C1-set: Immunoglobulin C1-set domain (119 - 199)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DO alpha chain

HLA-D0-alpha

Related Diseases

Diseases Alias
Hirata Disease

Insulin Autoimmune Syndrome

Insulin Autoimmune Hypoglycemia
Granulomatosis With Polyangiitis

GPA

Wegener Granulomatosis

Wegener Granulomatosis, Formerly

Midline Granulomatosis

Wg, Formerly

Necrotizing Respiratory Granulomatosis

Wg

Wegeners Granulomatosis

Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06201 HLA-DOA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-DOA RGD RGD:3477
Mus musculus HLA-DOA MGD MGI:95924