HLA-DOA - major histocompatibility complex, class II, DO alpha Gene

Also Known as HLADZ; HLA-DNA; HLA-DZA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3111

About HLA-DOA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,004,182-33,009,591 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 89 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 26.6), spleen (RPKM 26.2) and 20 other tissues.

Summary

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

HLA-DOA Products (1)

mRNA Protein Name
NM_002119.4 NP_002110.1 HLA class II histocompatibility antigen, DO alpha chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MHC class II protein complex binding IDA
IDA: Inferred from direct assay
22733780 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
22733780 GOA
Cellular Component GO Annotation Evidence References Source
part of MHC class II protein complex IDA
IDA: Inferred from direct assay
22733780 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DOA Protein Structure

MHC_II_alpha

MHC_II_alpha: Class II histocompatibility antigen, alpha domain (29 - 110)

C1-set

C1-set: Immunoglobulin C1-set domain (119 - 199)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DO alpha chain

  • HLA-D0-alpha

Related Diseases

Diseases Alias
Hirata Disease

  • Insulin Autoimmune Syndrome

  • Insulin Autoimmune Hypoglycemia
Granulomatosis With Polyangiitis

  • GPA

  • Wegener Granulomatosis

  • Wegener Granulomatosis, Formerly

  • Midline Granulomatosis

  • Wg, Formerly

  • Necrotizing Respiratory Granulomatosis

  • Wg

  • Wegeners Granulomatosis

  • Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06201 HLA-DOA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-DOA RGD RGD:3477
Mus musculus HLA-DOA MGD MGI:95924