2. Gene
  3. HLA-DOB - major histocompatibility complex, class II, DO beta Gene

HLA-DOB - major histocompatibility complex, class II, DO beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DOB; HLA_DOB

Gene ID: 3112 | Gene type: protein coding

About HLA-DOB

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,812,763-32,817,002 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 89 orthologues and 13 paralogues. Biased expression in lymph node (RPKM 34.2), spleen (RPKM 22.4) and 9 other tissues.

Summary

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DOB Products(1)

mRNA Protein Name
NM_002120.4 NP_002111.1 HLA class II histocompatibility antigen, DO beta chain precursor

HLA-DOB Protein Structure

MHC_II_beta

MHC_II_beta: Class II histocompatibility antigen, beta domain (40 - 111)

C1-set

C1-set: Immunoglobulin C1-set domain (134 - 210)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DO beta chain

MHC class II antigen DOB

Related Diseases

Diseases Alias
Kawasaki Disease

Mucocutaneous Lymph Node Syndrome

Acute Febrile Mucocutaneous Lymph Node Syndrome

Kawasaki Syndrome

Kd

Infantile Polyarteritis

Kawasaki Disease, Susceptibility To

Acute Febrile Mcls

Kawasaki'S Disease

Mlns

KWD
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06202 HLA-DOB Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-DOB RGD RGD:1595814
Mus musculus HLA-DOB MGD MGI:95925