HLA-DOB - major histocompatibility complex, class II, DO beta Gene

Also Known as DOB; HLA_DOB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3112

About HLA-DOB

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,812,763-32,817,002 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 89 orthologues and 13 paralogues. Biased expression in lymph node (RPKM 34.2), spleen (RPKM 22.4) and 9 other tissues.

Summary

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DOB Products (1)

mRNA Protein Name
NM_002120.4 NP_002111.1 HLA class II histocompatibility antigen, DO beta chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MHC class II protein complex binding IDA
IDA: Inferred from direct assay
22733780 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
22733780 GOA
Cellular Component GO Annotation Evidence References Source
part of MHC class II protein complex IDA
IDA: Inferred from direct assay
22733780 GOA
located in lysosome IDA
IDA: Inferred from direct assay
8890155 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DOB Protein Structure

MHC_II_beta

MHC_II_beta: Class II histocompatibility antigen, beta domain (40 - 111)

C1-set

C1-set: Immunoglobulin C1-set domain (134 - 210)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DO beta chain

  • MHC class II antigen DOB

Related Diseases

Diseases Alias
Kawasaki Disease

  • Mucocutaneous Lymph Node Syndrome

  • Acute Febrile Mucocutaneous Lymph Node Syndrome

  • Kawasaki Syndrome

  • Kd

  • Infantile Polyarteritis

  • Kawasaki Disease, Susceptibility To

  • Acute Febrile Mcls

  • Kawasaki'S Disease

  • Mlns

  • KWD
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06202 HLA-DOB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-DOB RGD RGD:1595814
Mus musculus HLA-DOB MGD MGI:95925