Lrrc8a - leucine rich repeat containing 8 VRAC subunit A Gene

Also Known as Lrrc8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311846

Summary

Enables volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; response to osmotic stress; and taurine transport. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Lrrc8a Products (1)

mRNA Protein Name
NM_001024782.1 NP_001019953.1 volume-regulated anion channel subunit LRRC8A

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables volume-sensitive anion channel activity IMP
IMP: Inferred from mutant phenotype
28833202 RGD
Biological Process GO Annotation Evidence References Source
involved in aspartate transmembrane transport IMP
IMP: Inferred from mutant phenotype
28833202 RGD
involved in response to osmotic stress IMP
IMP: Inferred from mutant phenotype
28833202 RGD
involved in taurine transmembrane transport IMP
IMP: Inferred from mutant phenotype
28833202 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

volume-regulated anion channel subunit LRRC8A

  • leucine rich repeat containing 8 family, member A

  • leucine rich repeat containing 8A

  • leucine-rich repeat-containing 8

  • leucine-rich repeat-containing protein 8A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173189 2-5A Inhibitor / Unkown
HY-RS07827 LRRC8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21148 Lrrc8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27665 Lrrc8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrc8a NCBI NCBI:56262