HOXA7 - homeobox A7 Gene

Also Known as ANTP; HOX1; HOX1A; HOX1.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3204

About HOXA7

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,153,716-27,156,675 (from NCBI)

This gene has 3 transcripts (splice variants), 169 orthologues and 42 paralogues. Broad expression in kidney (RPKM 9.4), adrenal (RPKM 7.6) and 14 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]

HOXA7 Products (1)

mRNA Protein Name
NM_006896.4 NP_008827.2 homeobox protein Hox-A7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11435435 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18973687 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11435435 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11435435 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
17972163 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11435435 GOA
involved in negative regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
14704364 GOA
acts upstream of or within negative regulation of keratinocyte differentiation IDA
IDA: Inferred from direct assay
11435435 GOA
involved in negative regulation of leukocyte migration IDA
IDA: Inferred from direct assay
14704364 GOA
involved in negative regulation of monocyte differentiation IDA
IDA: Inferred from direct assay
14704364 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11435435 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11435435 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11435435 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA7 Protein Structure

Homeobox

Homeobox: Homeobox domain (131 - 187)

  • 0
  • 100
  • 200
  • 230 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-A7

  • homeo box A7

Related Diseases

Diseases Alias
Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay

  • CAKUTHED

  • Doid:0112359

  • Anomalies, Congenital, Kidney And Urinary Tract Syndrome With/Without Hearing Loss, Abnormal Ears, Or Developmental Delay
Sacrum Chordoma
Ovarian Serous Cystadenofibroma
Ovarian Serous Adenofibroma
Acute Leukemia

  • Stem Cell Leukaemia

  • Stem Cell Leukemia

  • Acute Leukemias

  • Acute Undifferentiated Leukemia

  • Undifferentiated Leukemia

  • Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

  • Blast Cell Leukaemia

  • Blast Leukaemia

  • Blastic Leukaemia

  • Undifferentiated Leukaemia
Hyperinsulinemic Hypoglycemia, Familial, 4

  • Hyperinsulinism Due To Glutamodehydrogenase Deficiency

  • HHF4

  • Familial Hyperinsulinemic Hypoglycemia 4

  • Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

  • Hyperinsulinism Due To Schad Deficiency

  • Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

  • Congenital Hyperinsulinism

  • Schad Deficiency

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies

  • Murcs Association

  • Mayer-Rokitansky-Kuster-Hauser Syndrome Type 2

  • Mrkh Syndrome Type 2

  • Mayer-Rokitansky-Küster-Hauser Syndrome Type 2

  • MURCS

  • Klippel-Feil Deformity, Conductive Deafness, And Absent Vagina

  • Atypical Mrkh Syndrome

  • Mullerian Duct Aplasia-Renal Dysplasia-Cervical Somite Anomalies Syndrome

  • Mayer-Rokitansky-Kuster-Hauser Syndrome, Type Ii

  • Mrkh, Type Ii

  • Mullerian Duct Aplasia, Unilateral Renal Aplasia, And Cervicothoracic Somite Dysplasia

  • Klippel-Feil Deformity - Conductive Deafness - Absent Vagina

  • Müllerian Aplasia - Renal Aplasia - Cervicothoracic Somite Dysplasia
Mayer-Rokitansky-Kuster-Hauser Syndrome

  • Mrkh Syndrome

  • Rokitansky Syndrome

  • Mullerian Aplasia

  • Mrkh Anomaly

  • Congenital Absence Of Uterus And Vagina

  • Congenital Absence Of The Uterus And Vagina

  • Genital Renal Ear Syndrome

  • Mayer-Rokitansky-Küster-Hauser Syndrome

  • Mullerian Dysgenesis

  • Müllerian Agenesis

  • Rokitansky Kuster Hauser Syndrome

  • MRKH

  • Mullerian Aplasia/Dysgenesis

  • Von Mayer-Rokitansky-Kuster Anomaly

  • Mrk Anomaly

  • Uterus Bipartitus Solidus Rudimentarius Cum Vagina Solida

  • Cauv

  • Mullerian Agenesis

  • Aplasia Of The Mullerian Ducts

  • Mullerian Duct Failure

  • Müllerian Aplasia

  • Rokitansky-Kuster-Hauser Syndrome

  • RKH SYNDROME
Mullerian Aplasia And Hyperandrogenism

  • Mullerian Duct Failure And Hyperandrogenism

  • Wnt4 Deficiency

  • Müllerian Aplasia And Hyperandrogenism

  • Biason-Lauber Syndrome

  • Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome

  • Mayer-Rokitansky-Küster-Hauser-Like Syndrome

  • Müllerian Duct Failure

  • Wnt4 Müllerian Aplasia

  • Wnt4 Müllerian Aplasia And Ovarian Dysfunction

  • MULLAPL

  • Wnt4 Mullerian Aplasia And Ovarian Dysfunction
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06302 HOXA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HOXA7 MGD MGI:96179
Rattus norvegicus HOXA7 RGD RGD:1587253
Felis catus HOXA7 VGNC VGNC:67620
Macaca mulatta HOXA7 VGNC VGNC:73503
Canis familiaris HOXA7 VGNC VGNC:49910
Bos taurus HOXA7 VGNC VGNC:29915
Others HOXA7 NCBI