IFNA14 - interferon alpha 14 Gene

Also Known as LEIF2H; IFN-alphaH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3448

About IFNA14

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,239,002-21,240,005 (from NCBI)

This gene has 1 transcript (splice variant), 583 orthologues and 16 paralogues.

Summary

Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

IFNA14 Products (1)

mRNA Protein Name
NM_002172.3 NP_002163.2 interferon alpha-14 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNA14 Protein Structure

Interferon

Interferon: Interferon alpha/beta domain (26 - 187)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

interferon alpha-14

  • IFN-alpha-14

IFNA14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFNA14 P01570 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
IFNA14 P01570 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
IFNA14 P01570 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNA14 Proteins

Cat. No. Product Name Accession Purity
HY-P72243 IFN-alpha 14/IFNA14 Protein, Human (His-SUMO) P01570 (C24-D189) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 22

  • DFNB22

  • Autosomal Recessive Nonsyndromic Deafness 22

  • Autosomal Recessive Deafness 22

  • Deafness, Autosomal Recessive, 22

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 22

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 22
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06572 IFNA14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18865 Ifna14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Others IFNA14 NCBI