GLS - glutaminase Gene

Also Known as GA; PAG

Species: Sus scrofa

Gene Type: protein coding
Gene ID: 399525

About GLS

Primary_assembly 15: 95,513,446-95,598,311 forward strand.Sscrofa11.1:CM000826.5

This gene has 3 transcripts (splice variants), 305 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 15.3), kidney (RPKM 13.3) and 8 other tissues.

GLS Products (6)

mRNA Protein Name
XM_021076051.1 XP_020931710.1 glutaminase kidney isoform, mitochondrial isoform X2
XM_021076052.1 XP_020931711.1 glutaminase kidney isoform, mitochondrial isoform X3
XM_021076049.1 XP_020931708.1 glutaminase kidney isoform, mitochondrial isoform X1
XM_021076054.1 XP_020931713.1 glutaminase kidney isoform, mitochondrial isoform X5
XM_021076053.1 XP_020931712.1 glutaminase kidney isoform, mitochondrial isoform X4
XM_021076050.1 XP_020931709.1 glutaminase kidney isoform, mitochondrial isoform X1

GLS Protein Structure

EF-hand_14

EF-hand_14: pfam17959 (138 - 221)

Glutaminase

Glutaminase: pfam04960 (243 - 527)

Ank_2

Ank_2: pfam12796 (556 - 648)

ANK

ANK: sd00045 (556 - 582)

ANK

ANK: sd00045 (584 - 616)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

glutaminase kidney isoform, mitochondrial

  • phosphate-activated glutaminase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-108917 Morphothiadin Inhibitor 99.79% Phase 2
HY-128357 Ibezapolstat Inhibitor 98.0% Phase 2
HY-12248A Telaglenastat hydrochloride 98.03% Phase 2
HY-P2760 Glutaminase Control / Phase 2
HY-108917A Morphothiadin mesylate Inhibitor / Phase 2
HY-128357A Ibezapolstat hydrochloride Inhibitor / Phase 2
HY-103671 IPN60090 Inhibitor 98.96% Phase 1
HY-103671A IPN60090 dihydrochloride Inhibitor 99.68% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99109 Zimberelimab Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150109A Purinostat Inhibitor 98.04% Unkown
HY-136704 GLS1 Inhibitor-1 Inhibitor 98.59% Unkown
HY-79583 Glutaminase-IN-3 Inhibitor 99.88% Unkown
HY-144666 GLS-1-IN-1 Inhibitor 99.83% Unkown
HY-RS05500 GLS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151434 GLS1 Inhibitor-6 / Unkown
HY-146616 GLS1 Inhibitor-3 Inhibitor / Unkown
HY-146617 GLS1 Inhibitor-4 / Unkown
HY-146658 Glutaminase-IN-4 Inhibitor / Unkown
HY-148241 A-446 Inhibitor / Unkown
HY-152207 LWG-301 / Unkown
HY-155138 GLS1 Inhibitor-7 Inhibitor / Unkown
HY-174211 JNK-IN-23 Inhibitor / Unkown
HY-179003 mTOR/GLS1-IN-1 / Unkown
HY-181890 TRG-192 Inhibitor / Unkown
HY-RS05501 Gls Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05502 Gls Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05503 GLS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17808 Gls2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24276 Gls2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990976 Brivestobart 99.198% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GLS NCBI NCBI:2744