2. Gene
  3. GLS - glutaminase Gene

GLS - glutaminase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GAC; GAM; KGA; GLS1; AAD20; DEE71; GDPAG; CASGID; EIEE71

Gene ID: 2744 | Gene type: protein coding

About GLS

Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:190,880,821-190,965,552 (from NCBI)

This gene has 15 transcripts (splice variants), 305 orthologues, 1 paralogue and is associated with 5 phenotypes. Broad expression in kidney (RPKM 48.0), small intestine (RPKM 21.8) and 22 other tissues.

Summary

This gene encodes the K-type mitochondrial Glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GLS Products(8)

mRNA Protein Name
XM_047443960.1 XP_047299916.1 glutaminase kidney isoform, mitochondrial isoform X4
XM_005246467.3 XP_005246524.1 glutaminase kidney isoform, mitochondrial isoform X2
XM_047443957.1 XP_047299913.1 glutaminase kidney isoform, mitochondrial isoform X3
XR_007072653.1
NM_014905.5 NP_055720.3 glutaminase kidney isoform, mitochondrial isoform 1 precursor
XM_047443958.1 XP_047299914.1 glutaminase kidney isoform, mitochondrial isoform X4
NM_001256310.2 NP_001243239.1 glutaminase kidney isoform, mitochondrial isoform 2
XM_006712435.1 XP_006712498.1 glutaminase kidney isoform, mitochondrial isoform X1

GLS Protein Structure

Glutaminase

Glutaminase: Glutaminase (244 - 530)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (557 - 643)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

glutaminase kidney isoform, mitochondrial

K-glutaminase

L-glutamine amidohydrolase

glutaminase C

glutaminase, phosphate-activated

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Infantile Cataract, Skin Abnormalities, Glutamate Excess, And Impaired Intellectual Development

CASGID
Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia
Global Developmental Delay, Progressive Ataxia, And Elevated Glutamine

GDPAG

Glutaminase Deficiency With Impaired Intellectual Development And Progressive Ataxia
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Developmental And Epileptic Encephalopathy 71

DEE71

Epileptic Encephalopathy, Early Infantile, 71

Glutaminase Deficiency With Neonatal Epileptic Encephalopathy

Eiee71

Developmental And Epileptic Encephalopathy, 71

Early Infantile Epileptic Encephalopathy 71

Neonatal Epileptic Encephalopathy Due To Glutaminase Deficiency
Hepatic Encephalopathy

Encephalopathy, Hepatic

Portal-Systemic Encephalopathy

Hepatoencephalopathy

He - [Hepatic Encephalopathy]

Hepatic Encephalopathy Nos

Hepatic Encephalopathy, Stage Unspecified

Hepatic Coma

Hepatocerebral Encephalopathy

Hepatocerebral Intoxication
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Spastic Ataxia-Dysarthria Due To Glutaminase Deficiency
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Pylorus Cancer

Ca Pylorus - Stomach

Malignant Neoplasm Of Prepylorus

Malignant Neoplasm Of Pylorus Of Stomach

Malignant Tumor Of Pylorus

Malignant Neoplasm Of Pylorus
Autosomal Recessive Disease

Autosomal Recessive Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-128357 Ibezapolstat Inhibitor 99.96% Phase 2
HY-P2760 Glutaminase / Phase 2
HY-103671A IPN60090 dihydrochloride Inhibitor 99.05% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99109 Zimberelimab Inhibitor 99.90% Phase 3
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108917 Morphothiadin Inhibitor 99.84% Unkown
HY-103671 IPN60090 Inhibitor 99.47% Unkown
HY-79583 Glutaminase-IN-3 Inhibitor 98.47% Unkown
HY-144666 GLS-1-IN-1 Inhibitor 99.64% Unkown
HY-151434 GLS1 Inhibitor-6 / Unkown
HY-12248A Telaglenastat hydrochloride / Unkown
HY-146616 GLS1 Inhibitor-3 Inhibitor / Unkown
HY-146617 GLS1 Inhibitor-4 / Unkown
HY-146658 Glutaminase-IN-4 Inhibitor / Unkown
HY-148241 A-446 Inhibitor / Unkown
HY-152207 LWG-301 / Unkown
HY-155138 GLS1 Inhibitor-7 Inhibitor / Unkown
HY-RS05500 GLS Human Pre-designed siRNA Set A / Unkown
HY-RS05501 Gls Mouse Pre-designed siRNA Set A / Unkown
HY-RS05502 Gls Rat Pre-designed siRNA Set A / Unkown
HY-RS05503 GLS2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GLS VGNC VGNC:62594
Mus musculus GLS MGD MGI:95752
Macaca mulatta GLS VGNC VGNC:99365
Bos taurus GLS VGNC VGNC:29419
Canis familiaris GLS VGNC VGNC:41276
Rattus norvegicus GLS RGD RGD:2707