2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. TRG-192

TRG-192 is a potent and selective glutaminase (GLS) inhibitor with an IC50 of 68 nM. TRG-192 inhibits intracellular glutamate levels. TRG-192 is applicable to related research on non-small cell lung cancer.

For research use only. We do not sell to patients.

TRG-192

TRG-192 Chemical Structure

CAS No. : 3080792-24-8

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TRG-192 Related Antibodies

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Description

TRG-192 is a potent and selective glutaminase (GLS) inhibitor with an IC50 of 68 nM. TRG-192 inhibits intracellular glutamate levels. TRG-192 is applicable to related research on non-small cell lung cancer[1].

IC50 & Target

IC50: 68 nM (GLS)[1]
In Vitro

TRG-192 potently inhibits glutaminase in cell-free in vitro biochemical assays, with an IC50 of 68 nM[1].
TRG-192 (0.01-1 μM; 72 h) potently inhibits the proliferation of glutamine-addicted NSCLC cell lines (A549, H460, H358), with IC50 values of 0.068 μM, 0.038 μM and 0.035 μM respectively after 72 h of treatment[1].
TRG-192 (0.3 μM; 24 h) significantly reduces intracellular glutamate levels in LDK378-resistant (LR) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TRG-192 Related Antibodies
Molecular Weight

630.59

Formula

C24H20F6N8O2S2
CAS No.
SMILES

O=C(NCC1=NC=CC(C(F)(F)F)=C1)C2=NN=C(CCCCC3=NN=C(C(NCC4=NC=CC(C(F)(F)F)=C4)=O)S3)S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRG-192 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRG-1923080792-24-8TRG192TRG 192GlutaminaseglutamineglutamateH460glutaminolysisA549H358LDK378-resistant cellsglutaminasenon-small cell lung cancerNSCLC cell linesInhibitorinhibitorinhibit

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