LRP3 - LDL receptor related protein 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4037

About LRP3

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,194,330-33,208,864 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues and 14 paralogues. Ubiquitous expression in ovary (RPKM 23.4), fat (RPKM 17.1) and 24 other tissues.

Summary

Involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in clathrin-coated pit. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRP3 Products (1)

mRNA Protein Name
NM_002333.4 NP_002324.2 low-density lipoprotein receptor-related protein 3 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
28340487 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28340487 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28340487 GOA
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
28340487 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRP3 Protein Structure

CUB

CUB: CUB domain (43 - 156)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (165 - 200)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (212 - 249)

CUB

CUB: CUB domain (254 - 362)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (455 - 489)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 3

  • 105 kDa low-density lipoprotein receptor-related protein

LRP3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83856 LRP3 Antibody (YA3553) WB, ICC/IF, FC, ELISA Human
HY-P83856A LRP3 Antibody (YA3553)(PBS only) WB, ICC/IF, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103715 NLRP3 modulator 1 Modulator / Unkown
HY-RS07798 LRP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17748 Lrp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24214 Lrp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LRP3 VGNC VGNC:68088
Macaca mulatta LRP3 VGNC VGNC:74444
Rattus norvegicus LRP3 RGD RGD:619729
Canis familiaris LRP3 VGNC VGNC:42776
Mus musculus LRP3 MGD MGI:3584516
Bos taurus LRP3 VGNC VGNC:30991
Others LRP3 NCBI