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H3-5 - H3.5 histone Gene

Also Known as H3.5; H3.3C; H3F3C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 440093

About H3-5

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:31,791,185-31,792,298 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]

H3-5 Products (1)

mRNA	Protein	Name
NM_001013699.3	NP_001013721.2	histone H3.3C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nucleosomal DNA binding	IDA IDA: Inferred from direct assay	21274551	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	21274551	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in euchromatin	IDA IDA: Inferred from direct assay	21274551	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3-5 Protein Structure

Histone

0
100
135 a.a.

Protein Preferred Names	Protein Names
histone H3.3C	H3 histone family member 3C

H3-5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	H3-5	Q6NXT2	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	H3-5	Q6NXT2	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	H3-5	Q6NXT2	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	H3-5	Q6NXT2	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	DNAJB6	Homo sapiens	O75190-2	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	DNAJB6	Homo sapiens	O75190-2	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	DNAJB6	Homo sapiens	O75190-2	Y2H Array	32814053
Intra	H3-5	Q6NXT2	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
Intra	H3-5	Q6NXT2	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	H3-5	Q6NXT2	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	DNAJC9	Homo sapiens	Q8WXX5	Y2H Prey Pooling	32296183
Intra	H3-5	Q6NXT2	DNAJC9	Homo sapiens	Q8WXX5	Y2H Array	32296183
Intra	H3-5	Q6NXT2	DNAJC9	Homo sapiens	Q8WXX5	Validated Y2H	32296183
Intra	H3-5	Q6NXT2	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	H3-5	Q6NXT2	RAN	Homo sapiens	P62826	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	RAN	Homo sapiens	P62826	Y2H Array	32814053
Intra	H3-5	Q6NXT2	RAN	Homo sapiens	P62826	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	FBLIM1	Homo sapiens	Q8WUP2	Y2H Array	32296183
Intra	H3-5	Q6NXT2	FBLIM1	Homo sapiens	Q8WUP2	Y2H Prey Pooling	32296183
Intra	H3-5	Q6NXT2	FBLIM1	Homo sapiens	Q8WUP2	Validated Y2H	32296183
Intra	H3-5	Q6NXT2	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	H3-5	Q6NXT2	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	LSAMP	Homo sapiens	Q13449	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	LSAMP	Homo sapiens	Q13449	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	LSAMP	Homo sapiens	Q13449	Y2H Array	32814053
Intra	H3-5	Q6NXT2	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	H3-5	Q6NXT2	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	CCK	Homo sapiens	P06307	Y2H Array	32814053
Intra	H3-5	Q6NXT2	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	NASP	Homo sapiens	P49321-2	Y2H Prey Pooling	32296183
Intra	H3-5	Q6NXT2	NASP	Homo sapiens	P49321-2	Y2H Array	32296183
Intra	H3-5	Q6NXT2	NASP	Homo sapiens	P49321-2	Validated Y2H	25416956
Intra	H3-5	Q6NXT2	HMOX2	Homo sapiens	P30519	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	HMOX2	Homo sapiens	P30519	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	HMOX2	Homo sapiens	P30519	Y2H Array	32814053
Intra	H3-5	Q6NXT2	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	H3-5	Q6NXT2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	H3-5	Q6NXT2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	H3-5	Q6NXT2	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
Intra	H3-5	Q6NXT2	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	H3-5	Q6NXT2	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	H3-5	Q6NXT2	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

H3-5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86113	Histone H3 (Di Methyl Lys4) Antibody (YA5805)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2557	Histone H3 (5-23)		/	Unkown
HY-RS05964	H3-5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W377455	2',5-Difluoro-2'-deoxy-1-arabinosyluracil		98.88%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	H3-5	MGD	MGI:3651714