H3-5 - H3.5 histone Gene

Homo sapiens

Also known as H3.5; H3.3C; H3F3C

Gene ID: 440093 | Gene type: protein coding

About H3-5

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:31,791,185-31,792,298 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]

H3-5 Products(1)

mRNA	Protein	Name
NM_001013699.3	NP_001013721.2	histone H3.3C

H3-5 Protein Structure

Histone

0
100
135 a.a.

Protein Preferred Names

Protein Names

histone H3.3C

H3 histone family member 3C

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05964	H3-5 Human Pre-designed siRNA Set A		/	Unkown
HY-W377455	2',5-Difluoro-2'-deoxy-1-arabinosyluracil		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	H3-5	MGD	MGI:3651714

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