Mknk1 - MAPK interacting serine/threonine kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 500526

About Mknk1

Primary_assembly 5: 129,318,170-129,357,639 forward strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 130 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in Spleen (RPKM 76.3), Adrenal (RPKM 75.9) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and regulation of translational initiation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mknk1 Products (1)

mRNA Protein Name
NM_001044267.1 NP_001037732.1 MAP kinase-interacting serine/threonine-protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16955078 RGD
Biological Process GO Annotation Evidence References Source
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
16955078 RGD
involved in regulation of translational initiation IMP
IMP: Inferred from mutant phenotype
16955078 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mknk1 Protein Structure

STKc_Mnk1

STKc_Mnk1: cd14174 (66 - 354)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
Protein Preferred Names Protein Names

MAP kinase-interacting serine/threonine-protein kinase 1

  • MAP kinase signal-integrating kinase 1

  • MAP kinase-interacting serine/threonine kinase 1

  • MAPK signal-integrating kinase 1

  • mnk1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-RS08473 MKNK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08474 Mknk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08475 Mknk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mknk1 NCBI NCBI:8569