Postn - periostin, osteoblast specific factor Gene

Also Known as PN; PLF; Osf2; OSF-2; A630052E07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50706

Summary

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in Cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Postn Products (6)

mRNA Protein Name
NM_001198765.1 NP_001185694.1 periostin isoform 2 precursor
NM_001198766.1 NP_001185695.1 periostin isoform 3 precursor
NM_001313898.1 NP_001300827.1 periostin isoform 4 precursor
NM_001313899.1 NP_001300828.1 periostin isoform 5 precursor
NM_001368678.1 NP_001355607.1 periostin isoform 6 precursor
NM_015784.3 NP_056599.1 periostin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
7663166 MGI
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IDA
IDA: Inferred from direct assay
10404027 MGI
involved in cellular response to vitamin K IDA
IDA: Inferred from direct assay
18450759 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
16314533 MGI
acts upstream of or within regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
19723774 MGI
acts upstream of or within tissue development IMP
IMP: Inferred from mutant phenotype
16314533 MGI
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
18450759 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
10404027 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

periostin

  • osteoblast specific factor 2 (fasciclin I-like)

  • osteoblast-specific factor 2

  • periostin-like factor

Recombinant Postn Proteins

Cat. No. Product Name Accession Purity
HY-P73373 Periostin Protein, Mouse (HEK293, His) Q62009-1 (N24-Q811) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78332 Periostin Protein, Mouse (Q62009-2, HEK293, His) Q62009-2/NP_056599.1 (N24-Q811) ≥ 90%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10884 POSTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16974 Postn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23417 Postn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Postn NCBI NCBI:10631