PI15 - peptidase inhibitor 15 Gene

Homo sapiens

Also known as P24TI; P25TI; CRISP8

Gene ID: 51050 | Gene type: protein coding

About PI15

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:74,824,534-74,855,029 (from NCBI)

This gene has 3 transcripts (splice variants), 275 orthologues and 13 paralogues. Biased expression in appendix (RPKM 36.9), prostate (RPKM 13.1) and 3 other tissues.

Summary

This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]

PI15 Products(2)

mRNA	Protein	Name
NM_001324403.2	NP_001311332.1	peptidase inhibitor 15 preproprotein
NM_015886.5	NP_056970.1	peptidase inhibitor 15 preproprotein

PI15 Protein Structure

CAP

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

peptidase inhibitor 15

25 kDa trypsin inhibitor

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Corneal Dystrophy, Meesmann, 1

Meesmann Corneal Dystrophy	Mecd
Corneal Dystrophy, Meesmann Epithelial	Juvenile Hereditary Epithelial Dystrophy
Corneal Dystrophy, Juvenile Epithelial Of Meesmann	MECD1
Meesmann Corneal Dystrophy 1	Meesmann Corneal Epithelial Dystrophy
Meesmann Epithelial Corneal Dystrophy	Corneal Dystrophy, Juvenile Epithelial, Of Meesmann
Stocker-Holt Dystrophy	Meesman Dystrophy
Meesman'S Corneal Dystrophy	Juvenile Hereditary Epithelial Dystrophy Of Meesmann
Corneal Dystrophy, Meesmann 1	Juvenile Epithelial Corneal Dystrophy Of Meesmann
Mcd	Dystrophy, Corneal, Meesmann

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10461	PI15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PI15	RGD	RGD:1309577
Mus musculus	PI15	MGD	MGI:1934659
Macaca mulatta	PI15	VGNC	VGNC:81496
Canis familiaris	PI15	VGNC	VGNC:44514
Bos taurus	PI15	VGNC	VGNC:32852