CUTC - cutC copper transporter Gene

Also Known as CGI-32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51076

About CUTC

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,732,234-99,756,134 (from NCBI)

This gene has 4 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in testis (RPKM 21.2), fat (RPKM 18.2) and 25 other tissues.

Summary

Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]

CUTC Products (1)

mRNA Protein Name
NM_015960.3 NP_057044.2 copper homeostasis protein cutC homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper ion binding IDA
IDA: Inferred from direct assay
19878721 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in protein tetramerization IPI
IPI: Inferred from physical interaction
19878721 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16182249 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16182249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUTC Protein Structure

CutC

CutC: CutC family (27 - 226)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

copper homeostasis protein cutC homolog

  • cutC copper transporter homolog

CUTC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CUTC Q9NTM9 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CUTC Q9NTM9 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CUTC Q9NTM9 XPO7 Homo sapiens Q9UIA9
Anti Tag CoIP
35271311
Intra
CUTC Q9NTM9 XPO7 Homo sapiens Q9UIA9
Anti Tag CoIP
29748336
Intra
CUTC Q9NTM9 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra
CUTC Q9NTM9 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
CUTC Q9NTM9 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
CUTC Q9NTM9 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
CUTC Q9NTM9 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
CUTC Q9NTM9 SPG21 Homo sapiens Q9NZD8
Y2H Array
25416956
Intra
CUTC Q9NTM9 SPG21 Homo sapiens Q9NZD8
Y2H Array
31515488
Intra
CUTC Q9NTM9 BCL6 Homo sapiens P41182
Validated Y2H
25416956
Intra
CUTC Q9NTM9 BCL6 Homo sapiens P41182
Y2H Prey Pooling
25416956
Intra
CUTC Q9NTM9 BCL6 Homo sapiens P41182
Y2H Array
25416956
Intra
CUTC Q9NTM9 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
32296183
Intra
CUTC Q9NTM9 ATXN1 Homo sapiens P54253
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CUTC Proteins

Cat. No. Product Name Accession Purity
HY-P75316 CUTC Protein, Human (His) Q9NTM9 (M1-V273) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Trimethylaminuria

  • TMAU

  • Fish-Odor Syndrome

  • Fish Malodor Syndrome

  • Fish Odor Syndrome

  • Stale Fish Syndrome

  • Tmauria

  • Severe Primary Trimethylaminuria

  • Mesh

  • D008661

  • Fish Odour Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03368 CUTC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19889 Cutc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26389 Cutc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CUTC VGNC VGNC:39737
Mus musculus CUTC MGD MGI:1913638
Macaca mulatta CUTC VGNC VGNC:106028
Bos taurus CUTC VGNC VGNC:27838
Felis catus CUTC VGNC VGNC:61290
Rattus norvegicus CUTC RGD RGD:1304966
Others CUTC NCBI