Sco1 - SCO1 cytochrome c oxidase assembly protein Gene

Also Known as D11Bwg1310e; 2610001C07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 52892

Summary

Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including cyclooxygenase pathway; mitochondrial cytochrome c oxidase assembly; and negative regulation of protein kinase B signaling. Located in mitochondrion. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; submandibular gland primordium; and vascular element. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human SCO1 (synthesis of cytochrome C oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sco1 Products (1)

mRNA Protein Name
NM_001040026.1 NP_001035115.1 protein SCO1 homolog, mitochondrial

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within copper ion homeostasis IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within cyclooxygenase pathway IMP
IMP: Inferred from mutant phenotype
28973536 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within intracellular copper ion homeostasis IDA
IDA: Inferred from direct assay
28647369 MGI
acts upstream of or within intracellular copper ion homeostasis IMP
IMP: Inferred from mutant phenotype
25683716 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within leukocyte differentiation IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within mitochondrial cytochrome c oxidase assembly IMP
IMP: Inferred from mutant phenotype
25683716 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within negative regulation of cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
28973536 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
28647369 MGI
acts upstream of or within negative regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25683716 MGI
acts upstream of or within post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
28973536 MGI
acts upstream of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25683716 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
28973536 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within regulation of cytochrome-c oxidase activity IMP
IMP: Inferred from mutant phenotype
28973536 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
36301669 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
19837698 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein SCO1 homolog, mitochondrial

  • SCO cytochrome oxidase deficient homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07320 Kit Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12556 SCO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19161 Sco1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25650 Sco1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sco1 NCBI NCBI:6341