RNF186 - ring finger protein 186 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54546

About RNF186

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,814,029-19,815,283 (from NCBI)

This gene has 1 transcript (splice variant) and 87 orthologues.

Summary

Enables ubiquitin-protein transferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF186 Products (1)

mRNA Protein Name
NM_019062.2 NP_061935.1 E3 ubiquitin-protein ligase RNF186

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
23896122 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
33280498 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
23896122 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
23896122 GOA
Biological Process GO Annotation Evidence Références Source
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
23896122 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23896122 GOA
involved in protein K29-linked ubiquitination IDA
IDA: Inferred from direct assay
23896122 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
23896122 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
23896122 GOA
involved in protein localization to mitochondrion IMP
IMP: Inferred from mutant phenotype
23896122 GOA
acts upstream of positive effect regulation of autophagosome assembly IDA
IDA: Inferred from direct assay
33280498 GOA
Cellular Component GO Annotation Evidence Références Source
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23896122 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23896122 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF186

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 9

  • IBD9
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

  • Autosomal Dominant Adult-Onset Proximal Sma

  • Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type

  • Finkel Disease

  • Smafk

  • Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant

  • Autosomal Dominant Adult Proximal Spinal Muscular Atrophy

  • Finkel Late-Adult Type Sma
Immunodeficiency 60

  • Bach2-Related Immunodeficiency And Autoimmunity

  • Brida

  • Imd60
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12070 RNF186 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21922 Rnf186 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28438 Rnf186 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RNF186 MGD MGI:1914075
Rattus norvegicus RNF186 RGD RGD:1596075
Canis familiaris RNF186 VGNC VGNC:45649
Bos taurus RNF186 VGNC VGNC:34043
Others RNF186 NCBI