PKIB - cAMP-dependent protein kinase inhibitor beta Gene

Homo sapiens

Also known as PRKACN2

Gene ID: 5570 | Gene type: protein coding

About PKIB

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,471,921-122,726,373 (from NCBI)

This gene has 13 transcripts (splice variants), 112 orthologues and 2 paralogues. Biased expression in colon (RPKM 18.8), placenta (RPKM 15.5) and 10 other tissues.

Summary

This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PKIB Products(6)

mRNA	Protein	Name
NM_001270393.2	NP_001257322.1	cAMP-dependent protein kinase inhibitor beta isoform 1
NM_001270394.2	NP_001257323.1	cAMP-dependent protein kinase inhibitor beta isoform 2
NM_001270395.2	NP_001257324.1	cAMP-dependent protein kinase inhibitor beta isoform 2
NM_032471.6	NP_115860.1	cAMP-dependent protein kinase inhibitor beta isoform 1
NM_181794.3	NP_861459.1	cAMP-dependent protein kinase inhibitor beta isoform 1
NM_181795.3	NP_861460.1	cAMP-dependent protein kinase inhibitor beta isoform 1

PKIB Protein Structure

PKI

0
78 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase inhibitor beta

PKI-beta

Recombinant PKIB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71209	PKI-beta Protein, Human (His)	Q9C010 (M1-K78)	≥95%

Related Diseases

Diseases

Alias

Benign Essential Hypertension

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10599	PKIB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PKIB	VGNC	VGNC:44608
Bos taurus	PKIB	VGNC	VGNC:32941
Mus musculus	PKIB	MGD	MGI:101937
Rattus norvegicus	PKIB	RGD	RGD:3335
Felis catus	PKIB	VGNC	VGNC:68875
Macaca mulatta	PKIB	VGNC	VGNC:83443
Others	PKIB	NCBI