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PKIB - cAMP-dependent protein kinase inhibitor beta Gene

Also Known as PRKACN2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5570

About PKIB

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,471,921-122,726,373 (from NCBI)

This gene has 13 transcripts (splice variants), 112 orthologues and 2 paralogues. Biased expression in colon (RPKM 18.8), placenta (RPKM 15.5) and 10 other tissues.

Summary

This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PKIB Products (6)

mRNA	Protein	Name
NM_001270393.2	NP_001257322.1	cAMP-dependent protein kinase inhibitor beta isoform 1
NM_001270394.2	NP_001257323.1	cAMP-dependent protein kinase inhibitor beta isoform 2
NM_001270395.2	NP_001257324.1	cAMP-dependent protein kinase inhibitor beta isoform 2
NM_032471.6	NP_115860.1	cAMP-dependent protein kinase inhibitor beta isoform 1
NM_181794.3	NP_861459.1	cAMP-dependent protein kinase inhibitor beta isoform 1
NM_181795.3	NP_861460.1	cAMP-dependent protein kinase inhibitor beta isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKIB Protein Structure

PKI

0
78 a.a.

Protein Preferred Names	Protein Names
cAMP-dependent protein kinase inhibitor beta	PKI-beta

Recombinant PKIB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71209	PKI-beta Protein, Human (His)	Q9C010-1 (M1-K78)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Benign Essential Hypertension
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10599	PKIB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18965	Pkib Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25455	Pkib Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PKIB	VGNC	VGNC:44608
Bos taurus	PKIB	VGNC	VGNC:32941
Mus musculus	PKIB	MGD	MGI:101937
Rattus norvegicus	PKIB	RGD	RGD:3335
Felis catus	PKIB	VGNC	VGNC:68875
Macaca mulatta	PKIB	VGNC	VGNC:83443
Others	PKIB	NCBI