PECR - peroxisomal trans-2-enoyl-CoA reductase Gene

Also Known as TERP; DCRRP; PVIARL; HPDHASE; SDR29C1; HSA250303

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55825

About PECR

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:216,029,088-216,081,809 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and is associated with 1 phenotype. Broad expression in liver (RPKM 14.1), fat (RPKM 7.2) and 15 other tissues.

Summary

Enables signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in phytol metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

PECR Products (1)

mRNA	Protein	Name
NM_018441.6	NP_060911.2	peroxisomal trans-2-enoyl-CoA reductase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables 2,4-dienoyl-CoA reductase (NADPH) activity	IDA IDA: Inferred from direct assay	11669066	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11669066	GOA
enables trans-2-enoyl-CoA reductase (NADPH) activity	IDA IDA: Inferred from direct assay	16546181	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phytol metabolic process	IDA IDA: Inferred from direct assay	16546181	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in peroxisome	IDA IDA: Inferred from direct assay	11669066	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PECR Protein Structure

adh_short_C2

0
100
200
303 a.a.

Protein Preferred Names	Protein Names
peroxisomal trans-2-enoyl-CoA reductase	2,4-dienoyl-CoA reductase-related protein

Related Diseases

Diseases	Alias
Hemopneumothorax	Haemopneumothorax
Ehlers-Danlos Syndrome, Hypermobility Type	Ehlers-Danlos Syndrome, Type 3 Ehlers-Danlos Syndrome, Type Iii EDSHMB Eds Iii Benign Hypermobility Syndrome Ehlers-Danlos Syndrome Hypermobility Type Eds3 Type Iii Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome Type 3 Es-D3
Brugada Syndrome 2	BRGDA2 Brugada Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10316	PECR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21405	Pecr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27924	Pecr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PECR	RGD	RGD:70925
Mus musculus	PECR	MGD	MGI:2148199
Canis familiaris	PECR	VGNC	VGNC:44411
Felis catus	PECR	VGNC	VGNC:64109
Macaca mulatta	PECR	VGNC	VGNC:75827
Bos taurus	PECR	VGNC	VGNC:32738
Others	PECR	NCBI