LRTM1 - leucine rich repeats and transmembrane domains 1 Gene

Also Known as HT017

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57408

About LRTM1

This gene has 2 transcripts (splice variants), 193 orthologues and 22 paralogues. Biased expression in spleen (RPKM 2.9), esophagus (RPKM 1.8) and 1 other tissue.

Summary

Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRTM1 Products (2)

mRNA Protein Name
NM_001304389.2 NP_001291318.1 leucine-rich repeat and transmembrane domain-containing protein 1 isoform 2
NM_020678.4 NP_065729.1 leucine-rich repeat and transmembrane domain-containing protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRTM1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (76 - 134)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and transmembrane domain-containing protein 1

Related Diseases

Diseases Alias
Congenital Fiber-Type Disproportion

  • Congenital Fiber Type Disproportion

  • Cftdm

  • Congenital Myopathy With Fiber Type Disproportion

  • Cftd

  • Congenital Fiber-Type Disproportion Myopathy

  • Fiber-Type Disproportion Myopathy, Congenital

  • Myopathy, Congenital With Fiber-Type Disproportion
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS28153 Lrtm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07846 LRTM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21635 Lrtm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LRTM1 VGNC VGNC:49805
Rattus norvegicus LRTM1 RGD RGD:2321691
Mus musculus LRTM1 MGD MGI:2442106
Macaca mulatta LRTM1 VGNC VGNC:82179
Felis catus LRTM1 VGNC VGNC:80616
Bos taurus LRTM1 VGNC VGNC:31046
Others LRTM1 NCBI