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LRRC4C - leucine rich repeat containing 4C Gene

Also Known as NGL1; NGL-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57689

About LRRC4C

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:40,114,199-41,459,652 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 22 paralogues. Biased expression in brain (RPKM 5.3), adrenal (RPKM 0.7) and 1 other tissue.

Summary

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]

LRRC4C Products (2)

mRNA	Protein	Name
NM_001258419.2	NP_001245348.1	leucine-rich repeat-containing protein 4C precursor
NM_020929.3	NP_065980.1	leucine-rich repeat-containing protein 4C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	23986473	GOA
enables cell-cell adhesion mediator activity	IGI IGI: Inferred from genetic interaction	23986473	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14595443	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of axonogenesis	IDA IDA: Inferred from direct assay	14595443	GOA
involved in synaptic membrane adhesion	IGI IGI: Inferred from genetic interaction	23986473	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	14595443	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC4C Protein Structure

LRR_5

LRR_1

LRR_8

I-set

0
100
200
300
400
500
600
640 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat-containing protein 4C	netrin-G1 ligand

LRRC4C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRRC4C	Q9HCJ2	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	LRRC4C	Q9HCJ2	NTNG1	Homo sapiens	Q9Y2I2	SPR	21946559
Intra	LRRC4C	Q9HCJ2	NTNG2	Homo sapiens	Q96CW9	SPR	21946559
Intra	LRRC4C	Q9HCJ2	DOLK	Homo sapiens	Q9UPQ8	Y2H Prey Pooling	32296183
Intra	LRRC4C	Q9HCJ2	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183
Intra	LRRC4C	Q9HCJ2	DOLK	Homo sapiens	Q9UPQ8	Anti Tag CoIP	33961781
Intra	LRRC4C	Q9HCJ2	DOLK	Homo sapiens	Q9UPQ8	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRRC4C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77102	NGL-1/LRRC4C Protein, Human (HEK293, His)	Q9HCJ2/NP_001245348.1 (Q45-K527)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 2	Epileptic Encephalopathy, Early Infantile, 2 DEE2 Eiee2 Issx2 Developmental And Epileptic Encephalopathy, 2 Infantile Spasm Syndrome, X-Linked 2 Early Infantile Epileptic Encephalopathy 2 X-Linked Infantile Spasm Syndrome 2 Atypical Rett Syndrome Cdkl5-Related Atypical Rett Syndrome Hanefeld Variant Infantile Spasm Syndrome X-Linked 2 Rett Syndrome Early-Onset Seizure Variant Rett Syndrome Variant With Infantile Spasms Encephalopathy, Epileptic, Early Infantile, Type 2
Colon Mucinous Adenocarcinoma	Colonic Mucinous Adenocarcinoma Mucinous Adenocarcinoma Of The Colon
Developmental And Epileptic Encephalopathy 1	Epileptic Encephalopathy, Early Infantile, 1 Infantile Epileptic-Dyskinetic Encephalopathy DEE1 Eiee1 Issx1 Xmesid X-Linked Infantile Spasm Syndrome 1 X-Linked Infantile Spasm Syndrome X-Linked Spasticity-Intellectual Disability-Epilepsy Syndrome Developmental And Epileptic Encephalopathy, 1 Infantile Epileptic Dyskinetic Encephalopathy Infantile Spasm Syndrome, X-Linked 1 West Syndrome, X-Linked Ohtahara Syndrome, X-Linked Early Infantile Epileptic Encephalopathy 1 Early Infantile Epileptic Encephalopathy-1 Issx X-Linked Ohtahara Syndrome X-Linked West Syndrome Infantile Spasm Syndrome X-Linked 1 Myoclonic Epilepsy X-Linked With Intellectual Disability And Spasticity Ohtahara Syndrome X-Linked West Syndrome X-Linked Encephalopathy, Epileptic, Early Infantile, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07822	LRRC4C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20174	Lrrc4c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26678	Lrrc4c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRRC4C	VGNC	VGNC:74391
Canis familiaris	LRRC4C	VGNC	VGNC:42803
Bos taurus	LRRC4C	VGNC	VGNC:31020
Rattus norvegicus	LRRC4C	RGD	RGD:1311013
Felis catus	LRRC4C	VGNC	VGNC:63304
Mus musculus	LRRC4C	MGD	MGI:2442636
Others	LRRC4C	NCBI