NGL-1/LRRC4C Protein, Human (HEK293, His)
Based on 1 Customer Validation
NGL-1/LRRC4C protein may promote neurite outgrowth of thalamic neurons, suggesting a role in neurodevelopment. The specific molecular mechanisms and their interactions with NTNG1 and WHRN require further study. NGL-1/LRRC4C Protein, Human (HEK293, His) is the recombinant human-derived NGL-1/LRRC4C protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
NGL-1/LRRC4C protein may promote neurite outgrowth of thalamic neurons, suggesting a role in neurodevelopment. The specific molecular mechanisms and their interactions with NTNG1 and WHRN require further study. NGL-1/LRRC4C Protein, Human (HEK293, His) is the recombinant human-derived NGL-1/LRRC4C protein, expressed by HEK293 , with C-His labeled tag.
Background
NGL-1/LRRC4C Protein is implicated in potentially promoting neurite outgrowth in developing thalamic neurons, suggesting its role in facilitating the intricate processes of neural development. The specific molecular mechanisms underlying its influence on neurite outgrowth remain to be fully elucidated, prompting further investigation into its functional significance in this context. Notably, NGL-1/LRRC4C interacts with NTNG1 and WHRN, implying potential molecular partnerships that may contribute to its regulatory roles in neurite extension. The proposed involvement of NGL-1/LRRC4C in promoting neurite outgrowth underscores its potential significance in shaping the connectivity and growth of developing thalamic neurons. In-depth research is essential to unravel the precise molecular pathways through which NGL-1/LRRC4C modulates neurite outgrowth and to understand its broader implications in neural development.
Verified Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Human NGL-1 at 2 μg/mL (100 μL/well) can bind Human NTNG1(HY-P71176). The KD for this effect is 3.325 nM.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-10*His
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Accession
Q9HCJ2/NP_001245348.1 (Q45-K527)
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Molecular Construction
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N-term
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LRRC4C (Q45-K527)
Accession # Q9HCJ2/NP_001245348.1 -
His
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C-term
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Protein Length
Partial
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Synonyms
LRRC4C; Leucine-Rich Repeat-Containing Protein 4C; Leucine Rich Repeat Containing 4C; Netrin-G Ligand-1; NGL-1; Netrin-G1 Ligand; KIAA1580; NGL1
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AA Sequence
QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTK
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Molecular Weight
Approximately 90-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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