RHEB - Ras homolog, mTORC1 binding Gene

Also Known as RHEB2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6009

About RHEB

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,466,012-151,519,895 (from NCBI)

This gene has 7 transcripts (splice variants), 123 orthologues and 35 paralogues. Ubiquitous expression in adrenal (RPKM 38.1), brain (RPKM 36.3) and 25 other tissues.

Summary

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

RHEB Products (1)

mRNA	Protein	Name
NM_005614.4	NP_005605.1	GTP-binding protein Rheb

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IMP IMP: Inferred from mutant phenotype	15728574	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	15728574	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	15340059	GOA
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	15728574	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17301792	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	29236692	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	15854902	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	29236692	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	12172553	GOA
involved in regulation of type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	19258434	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in endomembrane system	IDA IDA: Inferred from direct assay	22002721	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	24529379	GOA
is active in postsynaptic density	EXP EXP: Inferred from Experiment	27898073	GOA
is active in postsynaptic density	IDA IDA: Inferred from direct assay	27898073	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHEB Protein Structure

Ras

0
100
184 a.a.

Protein Preferred Names	Protein Names
GTP-binding protein Rheb	Ras homolog enriched in brain 2

RHEB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RHEB	Q15382	TPT1	Homo sapiens	P13693	Pull Down	17301792
Intra	RHEB	Q15382	TPT1	Homo sapiens	P13693	GDP/GTP Exchange	17301792
Intra	RHEB	Q15382	LAMP2	Homo sapiens	P13473-2	Anti Tag CoIP	28514442
Intra	RHEB	Q15382	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	RHEB	Q15382	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	RHEB	Q15382	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	RHEB	Q15382	PLD1	Homo sapiens	Q13393	Pull Down	18550814
Intra	RHEB	Q15382	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RHEB	Q15382	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RHEB	Q15382	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	RHEB	Q15382	MTOR	Homo sapiens	P42345	Pull Down	18550814
Intra	RHEB	Q15382	MTOR	Homo sapiens	P42345	Anti Tag CoIP	16098514
Intra	RHEB	Q15382	CCK	Homo sapiens	P06307	Y2H Array	32814053
Intra	RHEB	Q15382	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	RHEB	Q15382	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	RHEB	Q15382	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RHEB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71260	RHEB Protein, Human (GST)	Q15382 (M1-M184)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700268	RHEB Protein, Human (sf9, N-His)	Q15382 (M1-C181)	≥ 85%, as determined by reducing SDS-PAGE.

RHEB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80310	RHEB Antibody (YA094)	WB, ICC/IF, IHC-P, FC	Human, Mouse

Related Diseases

Diseases	Alias
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Hemimegalencephaly	Unilateral Megalencephaly Macrencephaly
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Kidney Angiomyolipoma	Angiomyolipoma Of Kidney Renal Angiomyolipoma
Subependymal Glioma	Mixed Subependymoma-Ependymoma Subependymal Astrocytoma Who Grade I Ependymal Tumor Glioma, Subependymal
Benign Ependymoma	Ependymoma Epithelial Ependymoma Who Grade Ii Ependymal Tumor Myxopapillary Ependymoma
Kidney Benign Neoplasm	Renal And Ureteral Tumor Benign Kidney Neoplasm
Subependymal Giant Cell Astrocytoma	Sega Astrocytoma Subependymal Giant Cell Subependymal Giant-Cell Astrocytoma
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14530	Pelitrexol		98.07%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124798	Rheb inhibitor NR1	Inhibitor	99.26%	Unkown
HY-172423	Darlifarnib	Inhibitor	/	Unkown
HY-17654	BIEGi-1	Inhibitor	/	Unkown
HY-RS11942	RHEB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17646	Rheb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24106	Rheb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RHEB	RGD	RGD:621840
Mus musculus	RHEB	MGD	MGI:97912
Bos taurus	RHEB	VGNC	VGNC:33939
Felis catus	RHEB	VGNC	VGNC:64609
Canis familiaris	RHEB	VGNC	VGNC:45551
Others	RHEB	NCBI