PLD1 - phospholipase D1 Gene

Homo sapiens

Also known as CVDD; CVDP1

Gene ID: 5337 | Gene type: protein coding

About PLD1

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:171,600,404-171,810,483 (from NCBI)

This gene has 16 transcripts (splice variants), 283 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in gall bladder (RPKM 28.0), duodenum (RPKM 12.6) and 24 other tissues.

Summary

This gene encodes a phosphatidylcholine-specific Phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The Enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]

PLD1 Products(2)

mRNA	Protein	Name
NM_001130081.3	NP_001123553.1	phospholipase D1 isoform b
NM_002662.5	NP_002653.1	phospholipase D1 isoform a

PLD1 Protein Structure

PLDc

PLDc_2

0
200
400
600
800
1000
1074 a.a.

Protein Preferred Names

Protein Names

phospholipase D1

choline phosphatase 1

Related Diseases

Diseases

Alias

Cardiac Valvular Dysplasia 1

Cardiac Valvular Defect, Developmental	CVDP1
CVDD	Heart Valve Disease

Coffin-Lowry Syndrome

CLS	Coffin Syndrome 1
Coffin Syndrome	Intellectual Disability With Osteocartilaginous Abnormalities
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Mental Retardation With Osteocartilaginous Abnormalities	Coffin Lowry Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12807	FIPI	Inhibitor	99.82%	Unkown
HY-108612	VU0155069	Inhibitor	98.04%	Unkown
HY-119093	Halopemide		99.65%	Unkown
HY-101293	VU0359595	Inhibitor	99.65%	Unkown
HY-155342	A3373	Inhibitor	99.06%	Unkown
HY-12807A	FIPI hydrochloride	Inhibitor	/	Unkown
HY-108612A	VU0155069 hydrochloride	Inhibitor	/	Unkown
HY-108616	VU 0364739 hydrochloride	Inhibitor	/	Unkown
HY-155343	A4333	Inhibitor	/	Unkown
HY-RS10670	PLD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLD1	VGNC	VGNC:76171
Bos taurus	PLD1	VGNC	VGNC:50244
Rattus norvegicus	PLD1	RGD	RGD:3349
Felis catus	PLD1	VGNC	VGNC:68901
Canis familiaris	PLD1	VGNC	VGNC:44660
Mus musculus	PLD1	MGD	MGI:109585

Name
Email *

	Sorry, but the email address you supplied was invalid.