RNASE4 - ribonuclease A family member 4 Gene

Also Known as RAB1; RNS4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6038

About RNASE4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,560-20,701,216 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues and 12 paralogues. Biased expression in liver (RPKM 129.2), fat (RPKM 38.7) and 12 other tissues.

Summary

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]

RNASE4 Products (4)

mRNA Protein Name
NM_001282192.2 NP_001269121.1 ribonuclease 4 precursor
NM_001282193.2 NP_001269122.1 ribonuclease 4 precursor
NM_002937.5 NP_002928.1 ribonuclease 4 precursor
NM_194431.3 NP_919412.1 ribonuclease 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA nuclease activity IDA
IDA: Inferred from direct assay
3467790 GOA
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IMP
IMP: Inferred from mutant phenotype
33818125 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
3467790 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
3467790 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNASE4 Protein Structure

RnaseA

RnaseA: Pancreatic ribonuclease (32 - 146)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

ribonuclease 4

  • RNase 4

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 9

  • Amyotrophic Lateral Sclerosis Type 9

  • ALS9

  • Sclerosis, Lateral, Amyotrophic, Type Type 9
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00684 ANG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12021 RNASE4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RNASE4 MGD MGI:1926217
Felis catus RNASE4 VGNC VGNC:104711
Rattus norvegicus RNASE4 RGD RGD:61823
Bos taurus RNASE4 VGNC VGNC:33998
Macaca mulatta RNASE4 VGNC VGNC:84760
Others RNASE4 NCBI