RNASE4 - ribonuclease A family member 4 Gene

Homo sapiens

Also known as RAB1; RNS4

Gene ID: 6038 | Gene type: protein coding

About RNASE4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,560-20,701,216 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues and 12 paralogues. Biased expression in liver (RPKM 129.2), fat (RPKM 38.7) and 12 other tissues.

Summary

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]

RNASE4 Products(4)

mRNA	Protein	Name
NM_001282192.2	NP_001269121.1	ribonuclease 4 precursor
NM_001282193.2	NP_001269122.1	ribonuclease 4 precursor
NM_002937.5	NP_002928.1	ribonuclease 4 precursor
NM_194431.3	NP_919412.1	ribonuclease 4 precursor

RNASE4 Protein Structure

RnaseA

0
100
147 a.a.

Protein Preferred Names

Protein Names

ribonuclease 4

RNase 4

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 9

Amyotrophic Lateral Sclerosis Type 9	ALS9
Sclerosis, Lateral, Amyotrophic, Type Type 9

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12021	RNASE4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNASE4	MGD	MGI:1926217
Felis catus	RNASE4	VGNC	VGNC:104711
Rattus norvegicus	RNASE4	RGD	RGD:61823
Bos taurus	RNASE4	VGNC	VGNC:33998
Macaca mulatta	RNASE4	VGNC	VGNC:84760

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