RREB1 - ras responsive element binding protein 1 Gene

Also Known as HNT; FINB; LZ321; Zep-1; RREB-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6239

About RREB1

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,107,743-7,251,980 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 4.1), colon (RPKM 3.6) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the Calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of Calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

RREB1 Products (4)

mRNA Protein Name
NM_001003698.4 NP_001003698.1 ras-responsive element-binding protein 1 isoform 2
NM_001003699.4 NP_001003699.1 ras-responsive element-binding protein 1 isoform 1
NM_001003700.2 NP_001003700.1 ras-responsive element-binding protein 1 isoform 3
NM_001168344.2 NP_001161816.1 ras-responsive element-binding protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8816445 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
20133935 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8816445 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20133935 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
18394891 GOA
involved in positive regulation of lamellipodium morphogenesis IMP
IMP: Inferred from mutant phenotype
18394891 GOA
involved in positive regulation of mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18394891 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
18394891 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8816445 GOA
involved in positive regulation of wound healing, spreading of epidermal cells IMP
IMP: Inferred from mutant phenotype
18394891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RREB1 Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (66 - 89)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (111 - 136)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (208 - 230)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (643 - 665)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (686 - 709)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1247 - 1268)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1395 - 1415)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (1526 - 1550)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1687 a.a.
Protein Preferred Names Protein Names

ras-responsive element-binding protein 1

  • DNA-binding protein

Related Diseases

Diseases Alias
Chromosome 22q11.2 Deletion Syndrome, Distal

  • 22q11.2 Deletion Syndrome

  • Autosomal Dominant Opitz G/Bbb Syndrome

  • Catch22

  • Cayler Cardiofacial Syndrome

  • Conotruncal Anomaly Face Syndrome

  • Digeorge Syndrome

  • Sedlackova Syndrome

  • Shprintzen Syndrome

  • Velocardiofacial Syndrome

  • 22q11.2 Distal Deletion Syndrome

  • Distal 22q11.2 Microdeletion Syndrome

  • 22q11.2ds

  • Vcfs

  • Velo-Cardio-Facial Syndrome

  • Distal Chromosome 22q11.2 Deletion Syndrome

  • Chromosome 22q11.2 Deletion Syndrome Distal

  • Chromosome 22q11.2 Deletion Syndrome

  • Deletion 22q11.2 Syndrome

  • 22q11ds

  • Catch 22

  • Digeorge Sequence

  • Microdeletion 22q11.2

  • Monosomy 22q11

  • Takao Syndrome

  • Distal Del(22)(Q11.2)

  • Distal Monosomy 22q11.2

  • Catch 22 Syndrome

  • Chromosome Deletion Syndrome 22q11.2, Distal
Scrotum Melanoma

  • Melanoma Of Scrotum
Spitzoid Melanoma

  • Atypical Spitz Nevus
Chromosome 6pter-P24 Deletion Syndrome

  • 6p Subtelomeric Deletion Syndrome

  • 6p25 Microdeletion Syndrome

  • Distal Monosomy 6p

  • Distal Deletion 6p

  • Monosomy 6p25
Tumoral Calcinosis, Normophosphatemic, Familial

  • Normophosphatemic Familial Tumoral Calcinosis

  • NFTC

  • Tumoral Calcinosis, Familial, Normophosphatemic

  • Calcinosis, Tumoral, With Normophosphatemia

  • Familial Normophosphatemic Tumoral Calcinosis

  • Tumoral Calcinosis With Normophosphatemia
Scrotum Neoplasm

  • Malignant Tumour Of Scrotum

  • Malignant Scrotal Neoplasm

  • Malignant Tumor Of Scrotum

  • Neoplasm Of Scrotum

  • Scrotal Ca

  • Scrotal Tumor

  • Scrotum Cancer

  • Cancer Of Scrotum

  • Malignant Neoplasm Of Scrotum

  • Scrotal Cancer

  • Malignant Scrotal Tumour

  • Malignant Neoplasm Of Skin Of Scrotum

  • Primary Malignant Neoplasm Of Scrotum
Thyroid Carcinoma, Familial Medullary

  • Medullary Thyroid Carcinoma

  • Familial Medullary Thyroid Carcinoma

  • MTC

  • Medullary Thyroid Cancer

  • Fmtc

  • Mtc1

  • Thyroid Cancer, Medullary

  • Thyroid Carcinoma, Medullary

  • Familial Mtc

  • Thyroid Carcinoma Medullary

  • Carcinoma, Thyroid, Medullary, Familial

  • Medullary Carcinoma Of Thyroid

  • Medullary Carcinoma With Amyloid Stroma, Unspecified Site

  • Medullary Carcinoma With Amyloid Stroma Of Thyroid
Vulvar Melanoma

  • Malignant Melanoma Of Vulva
Noonan Syndrome 1

  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12283 RREB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21041 Rreb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27559 Rreb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RREB1 RGD RGD:1310904
Felis catus RREB1 VGNC VGNC:64773
Macaca mulatta RREB1 VGNC VGNC:76939
Bos taurus RREB1 VGNC VGNC:34162
Canis familiaris RREB1 VGNC VGNC:45758
Mus musculus RREB1 MGD MGI:2443664
Others RREB1 NCBI