SLC28A3 - solute carrier family 28 member 3 Gene

Also Known as CNT3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64078

About SLC28A3

Cytogenetic location: 9q21.32-q21.33 Genomic coordinates (GRCh38): 9:84,275,457-84,368,727 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 2 paralogues. Biased expression in gall bladder (RPKM 4.2), bone marrow (RPKM 3.2) and 11 other tissues.

Summary

Nucleoside Transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

SLC28A3 Products (2)

mRNA Protein Name
NM_001199633.2 NP_001186562.1 solute carrier family 28 member 3
NM_022127.3 NP_071410.1 solute carrier family 28 member 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26481311 GOA
enables uridine transmembrane transporter activity IDA
IDA: Inferred from direct assay
22492015 GOA
Biological Process GO Annotation Evidence References Source
involved in nucleoside transmembrane transport IDA
IDA: Inferred from direct assay
22492015 GOA
involved in pyrimidine-containing compound transmembrane transport IDA
IDA: Inferred from direct assay
22492015 GOA
involved in uridine transmembrane transport IDA
IDA: Inferred from direct assay
22492015 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC28A3 Protein Structure

Nucleos_tra2_N

Nucleos_tra2_N: Na+ dependent nucleoside transporter N-terminus (206 - 277)

Gate

Gate: Nucleoside recognition (286 - 381)

Nucleos_tra2_C

Nucleos_tra2_C: Na+ dependent nucleoside transporter C-terminus (388 - 612)

  • 0
  • 200
  • 400
  • 600
  • 691 a.a.
Protein Preferred Names Protein Names

solute carrier family 28 member 3

  • concentrative Na(+)-nucleoside cotransporter 3

SLC28A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC28A3 Q9HAS3 LGALS4 Homo sapiens P56470
Pull Down
26481311
Intra
SLC28A3 Q9HAS3 LGALS4 Homo sapiens P56470
Confocal
26481311
Intra
SLC28A3 Q9HAS3 LGALS4 Homo sapiens P56470
Anti Bait CoIP
26481311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13152 SLC28A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC28A3 RGD RGD:621224
Macaca mulatta SLC28A3 VGNC VGNC:77493
Bos taurus SLC28A3 VGNC VGNC:34793
Mus musculus SLC28A3 MGD MGI:2137361
Felis catus SLC28A3 VGNC VGNC:65295
Others SLC28A3 NCBI