STMP1 - short transmembrane mitochondrial protein 1 Gene

Also Known as Mm47; C7orf73; PL-5283

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 647087

About STMP1

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,662,514-135,676,416 (from NCBI)

This gene has 4 transcripts (splice variants) and 121 orthologues. Ubiquitous expression in thyroid (RPKM 20.9), testis (RPKM 17.4) and 25 other tissues.

Summary

Predicted to be involved in positive regulation of NLRP3 inflammasome complex assembly and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrial intermembrane space and mitochondrial outer membrane. Predicted to be active in mitochondrial respirasome. [provided by Alliance of Genome Resources, Apr 2022]

STMP1 Products (1)

mRNA Protein Name
NM_001130929.2 NP_001124401.1 short transmembrane mitochondrial protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial cytochrome c oxidase assembly IMP
IMP: Inferred from mutant phenotype
35450818 GOA
involved in mitochondrial respirasome assembly IMP
IMP: Inferred from mutant phenotype
35450818 GOA
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
35450818 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STMP1 Protein Structure

DUF4535

DUF4535: Domain of unknown function (DUF4535) (3 - 45)

  • 0
  • 47 a.a.
Protein Preferred Names Protein Names

short transmembrane mitochondrial protein 1

  • uncharacterized protein C7orf73

STMP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STMP1 E0CX11 SGTA Homo sapiens O43765
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182964 WY165 Activator 99.00% Unkown
HY-RS22838 Stmp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13947 STMP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29353 Stmp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus STMP1 VGNC VGNC:53677
Felis catus STMP1 VGNC VGNC:102708
Mus musculus STMP1 MGD MGI:1914955
Rattus norvegicus STMP1 RGD RGD:1591053
Others STMP1 NCBI