Cplx1 - complexin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64832

Summary

Enables syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cplx1 Products (1)

mRNA Protein Name
NM_022864.4 NP_074055.1 complexin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
11751907 RGD
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
7553862 RGD
Biological Process GO Annotation Evidence References Source
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
11751907 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
7553862 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
7553862 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
10430466 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
10430466 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19255244 RGD
located in synapse IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
IDA: Inferred from direct assay
7553862 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complexin-1

  • CPX I

  • complexin I

  • synaphin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03097 CPLX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22455 Cplx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28978 Cplx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cplx1 NCBI NCBI:10815