SPIB - Spi-B transcription factor Gene

Also Known as SPI-B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6689

About SPIB

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,418,938-50,431,314 (from NCBI)

This gene has 8 transcripts (splice variants), 99 orthologues, 28 paralogues and is associated with 1 phenotype. Biased expression in lymph node (RPKM 17.1), appendix (RPKM 10.5) and 7 other tissues.

Summary

The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

SPIB Products (4)

mRNA Protein Name
NM_001243998.2 NP_001230927.1 transcription factor Spi-B isoform 2
NM_001243999.2 NP_001230928.1 transcription factor Spi-B isoform 3
NM_001244000.2 NP_001230929.2 transcription factor Spi-B isoform 4
NM_003121.5 NP_003112.2 transcription factor Spi-B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
10196196 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
10196196 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10196196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPIB Protein Structure

Ets

Ets: Ets-domain (169 - 253)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

transcription factor Spi-B

  • Spi-B transcription factor (Spi-1/PU.1 related)

SPIB Antibodies

Cat. No. Product Name Application Reactivity
HY-P84464 SPIB Antibody (YA4161) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse
HY-P84464A SPIB Antibody (YA4161)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse

Related Diseases

Diseases Alias
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Mcd Diffuse Large B-Cell Lymphoma

  • Mcd Dlbcl

  • Doid:0081066
Pitt-Hopkins Syndrome

  • PTHS

  • Encephalopathy, Severe Epileptic, With Autonomic Dysfunction

  • Mental Retardation, Syndromal, With Intermittent Hyperventilation

  • Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea

  • Pitt Hopkins Syndrome

  • Phs

  • Encephalopathy Severe Epileptic With Autonomic Dysfunction
Progressive Multifocal Leukoencephalopathy

  • Pml

  • Leukoencephalopathy, Progressive Multifocal

  • Progressive Multifocal Leukoencephalitis

  • Leukoencephalopathy Progressive Multifocal

  • Pml - [Progressive Multifocal Leukoencephalopathy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13672 SPIB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22331 Spib Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28853 Spib Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPIB MGD MGI:892986
Rattus norvegicus SPIB RGD RGD:1565899