Serpina12 - serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Gene

Also Known as 4632419J12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68054

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of gluconeogenesis; positive regulation of signal transduction; and regulation of lipid metabolic process. Located in extracellular space and plasma membrane. Is expressed in back skin. Orthologous to human SERPINA12 (Serpin family A member 12). [provided by Alliance of Genome Resources, Apr 2022]

Serpina12 Products (1)

mRNA Protein Name
NM_026535.2 NP_080811.1 serpin A12 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22837305 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of gluconeogenesis IDA
IDA: Inferred from direct assay
22837305 MGI
acts upstream of lipid biosynthetic process IDA
IDA: Inferred from direct assay
22837305 MGI
acts upstream of or within negative regulation of gluconeogenesis IDA
IDA: Inferred from direct assay
22837305 MGI
acts upstream of or within negative regulation of lipid biosynthetic process IDA
IDA: Inferred from direct assay
22837305 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
22837305 MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22837305 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
22837305 MGI
acts upstream of or within regulation of cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
22837305 MGI
acts upstream of or within regulation of triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
22837305 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
22837305 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22837305 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serpin A12

  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

  • vaspin

  • visceral adipose tissue-derived serine protease inhibitor

  • visceral adipose-specific SERPIN

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12698 SERPINA12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20676 Serpina12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27187 Serpina12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpina12 NCBI NCBI:145264