TSHB - thyroid stimulating hormone subunit beta Gene

Also Known as TSH-B; TSH-BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7252

About TSHB

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:115,029,826-115,034,309 (from NCBI)

This gene has 1 transcript (splice variant), 248 orthologues, 9 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

The four human glycoprotein Hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these Hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

TSHB Products (2)

mRNA	Protein	Name
NM_000549.5	NP_000540.2	thyrotropin subunit beta isoform 1 precursor
NM_001277991.1	NP_001264920.1	thyrotropin subunit beta isoform 2

TSHB Protein Structure

Cys_knot

0
100
138 a.a.

Protein Preferred Names	Protein Names
thyrotropin subunit beta	thyroid stimulating hormone beta

TSHB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83902	TSHB Antibody (YA3599)	IHC-P, FC, ELISA	Human
HY-P83902A	TSHB Antibody (YA3599)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86012	TSHB Antibody (YA5704)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Hypothyroidism, Congenital, Nongoitrous, 4	Tsh Deficiency CHNG4 Thyrotropin Deficiency, Isolated Pituitary Cretinism Congenital Nongoitrous Hypothyroidism 4 Isolated Thyrotropin Deficiency Thyroid-Stimulating Hormone Deficiency Hypothyroidism, Congenital, Nongoitrous 4 Thyroid-Stimulating Hormone, Deficiency Of Isolated Thyroid-Stimulating Hormone Deficiency Isolated Tsh Deficiency Hypothyroidism, Congenital, Nongoitrous, Type 4 Secondary Hypothyroidism Tsh - [Thyroid Stimulating Hormone] Deficiency
Central Congenital Hypothyroidism	Secondary Hypothyroidism
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Thyroiditis	Inflammation Of Thyroid Thyroiditis Nos
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Pituitary Hormone Deficiency, Combined, 2	Panhypopituitarism Combined Pituitary Hormone Deficiency CPHD2 Ateliotic Dwarfism With Hypogonadism Pituitary Dwarfism Iii Hanhart Dwarfism Simmond'S Disease Simmonds' Disease Cphd Pituitary Hormone Deficiency, Combined Hormone Deficiency, Pituitary, Combined, Type 2 Pituitary Dwarfism Type 3 Sheehan Syndrome
Suprasellar Meningioma
Thyroid Hormone Resistance, Selective Pituitary	PRTH Selective Pituitary Thyroid Hormone Resistance Selective Pituitary Resistance To Thyroid Hormone Familial Hyperthyroidism Due To Inappropriate Thyrotropin Secretion Hyperthyroidism, Familial, Due To Inappropriate Thyrotropin Secretion Pituitary Resistance To Thyroid Hormone
Hypothyroidism, Central, With Testicular Enlargement	X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement CHTE Hypothyroidism, Central, And Testicular Enlargement Igsf1 Deficiency Syndrome X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism Central Hypothyroidism And Testicular Enlargement Hypothyroidism, Central, Testicular Enlargement
Pituitary Adenoma	Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma Pituitary Neoplasms
Tsh Producing Pituitary Tumor	Thyrotroph Adenoma Tsh Producing Pituitary Tumour Tsh Secreting Adenoma Of The Pituitary Tsh Secreting Tumor Of Pituitary Tsh Secreting Tumour Of Pituitary Tsh-Secreting Pituitary Adenoma Pituitary Thyrotrophic Adenoma Tsh-Oma Thyroid Stimulating Hormone-Secreting Pituitary Adenoma Thyroid Stimulating Hormone-Producing Pituitary Tumor
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Thyroid Hormone Resistance, Generalized, Autosomal Dominant	Thyroid Hormone Resistance Syndrome Thyroid Hormone Resistance GRTHD Gthr Thyroid Hormone Unresponsiveness Generalized Thyroid Hormone Resistance Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Thyroid Hormones Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones Refetoff Syndrome Thyroid Hormone Responsiveness Defect Familial Euthyroid Hyperthyroxinemia, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Thyroid Gland Disease	Abnormality Of The Thyroid Gland Thyroid Diseases
Allan-Herndon-Dudley Syndrome	AHDS Allan-Herndon Syndrome Monocarboxylate Transporter 8 Deficiency MCT8 DEFICIENCY Mental Retardation, X-Linked, With Hypotonia Triiodothyronine Resistance T3 Resistance Mental Retardation And Muscular Atrophy Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency Intellectual Disability And Muscular Atrophy Monocarboxylate Transporter-8 Deficiency T3 Resisitence Triiodothyronine Resistence X-Linked Intellectual Disability With Hypotonia Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency Monocarboxylate Transporter 8 Deficiency X-Linked Intellectual Disability-Hypotonia Syndrome
Endemic Goiter	Iodine-Deficiency-Related Endemic Goitre Simple Goitre Goiter, Endemic Euthyroid Goiter
Hypothyroidism, Congenital, Nongoitrous, 1	Tsh Resistance CHNG1 Hypothyroidism Due To Tsh Receptor Mutations Thyrotropin Resistance Thyroid-Stimulating Hormone Rtsh Hypothyroidism Due To Unresponsiveness To Thyrotropin Congenital Nongoitrous Hypothyroidism 1 Thyroid-Stimulating Hormone, Resistance To Hypothyroidism, Nonautoimmune Hypothyroidism, Congenital, Due To Tsh Resistance Hypothyroidism, Congenital, Non-Goitrous, 1 Congenital Hypothyroidism Due To Tsh Resistance Non-Autoimmune Hypothyroidism Thyroid-Stimulating Hormone Resistance Hypothyroidism, Congenital, Nongoitrous, Type 1 Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome
Hypothalamic Disease	Hypothalamic Diseases Hypothalamic Dysfunction Hypothalamic Disorder Hypothalamic Dysfunction Syndromes
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Myxedema
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Umbilical Hernia	Hernia, Umbilical
Septooptic Dysplasia	Septo-Optic Dysplasia De Morsier Syndrome Growth Hormone Deficiency With Pituitary Anomalies SOD Pituitary Hormone Deficiency, Combined, 5 Septo-Optic Dysplasia Spectrum Septo-Optic Dysplasia With Growth Hormone Deficiency Pituitary Hormone Deficiency, Combined 5 Hypopituitarism And Septooptic 'Dysplasia' GHDPA CPHD5 Dysplasia, Septo-Optic Kallmann Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15144	TSHB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSHB	MGD	MGI:98848
Bos taurus	TSHB	VGNC	VGNC:36418
Rattus norvegicus	TSHB	RGD	RGD:3910
Felis catus	TSHB	VGNC	VGNC:66616
Macaca mulatta	TSHB	VGNC	VGNC:106526
Canis familiaris	TSHB	VGNC	VGNC:47901
Others	TSHB	NCBI