Ntf5 - neurotrophin 5 Gene

Also Known as NT4; NT-4; NT-5; Ntf4; NT4/5; Ntf-5; 2900040K06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78405

Summary

This gene encodes a secreted protein belonging to the neurotrophin family of structurally related molecules that play a crucial role in the control of neuronal numbers and of dendritic growth. The encoded preproprotein undergoes post-translational processing to generate non-covalently associated homodimeric functional protein. Mice deficient in the encoded protein exhibit a loss of sensory neurons in the nodose-petrosal and geniculate ganglia, have deficits in long-term memory and hippocampal long-lasting long-term potentiation. [provided by RefSeq, Oct 2015]

Ntf5 Products (1)

mRNA Protein Name
NM_198190.1 NP_937833.1 neurotrophin-4 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
10681461 MGI
involved in ameloblast differentiation IMP
IMP: Inferred from mutant phenotype
27015268 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
9973328 MGI
acts upstream of or within ganglion mother cell fate determination IMP
IMP: Inferred from mutant phenotype
10681461 MGI
acts upstream of or within innervation IDA
IDA: Inferred from direct assay
24378336 MGI
acts upstream of or within long-term memory IMP
IMP: Inferred from mutant phenotype
10869436 MGI
acts upstream of or within mechanoreceptor differentiation IGI
IGI: Inferred from genetic interaction
15376326 MGI
acts upstream of or within negative regulation of programmed cell death IDA
IDA: Inferred from direct assay
24378336 MGI
acts upstream of or within sensory organ boundary specification IMP
IMP: Inferred from mutant phenotype
10479455 MGI
acts upstream of or within taste bud development IDA
IDA: Inferred from direct assay
24378336 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurotrophin-4

  • neutrophic factor 4

Recombinant Ntf5 Proteins

Cat. No. Product Name Accession Purity
HY-P7273 NT-4 Protein, Mouse Q80VU4 (G80-A209) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09617 NTF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25451 Ntf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown