2. Gene
  3. CHAC1 - ChaC glutathione specific gamma-glutamylcyclotransferase 1 Gene

CHAC1 - ChaC glutathione specific gamma-glutamylcyclotransferase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 79094 | Gene type: protein coding

About CHAC1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,953,471-40,956,512 (from NCBI)

This gene has 3 transcripts (splice variants), 262 orthologues and 1 paralogue. Broad expression in esophagus (RPKM 2.7), pancreas (RPKM 2.0) and 19 other tissues.

Summary

This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of Cancer recurrence among breast and ovarian Cancer patients. [provided by RefSeq, Sep 2016]

CHAC1 Products(2)

mRNA Protein Name
NM_001142776.4 NP_001136248.2 glutathione-specific gamma-glutamylcyclotransferase 1 isoform b
NM_024111.6 NP_077016.3 glutathione-specific gamma-glutamylcyclotransferase 1 isoform a

CHAC1 Protein Structure

ChaC

ChaC: ChaC-like protein (75 - 248)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

glutathione-specific gamma-glutamylcyclotransferase 1

ChaC, cation transport regulator homolog 1

Related Diseases

Diseases Alias
Ovarian Embryonal Carcinoma

Embryonal Carcinoma Of Ovary

Embryonal Carcinoma Of The Ovary
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02590 CHAC1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CHAC1 VGNC VGNC:71125
Rattus norvegicus CHAC1 RGD RGD:1307153
Mus musculus CHAC1 MGD MGI:1916315
Felis catus CHAC1 VGNC VGNC:60832
Bos taurus CHAC1 VGNC VGNC:27262
Others CHAC1 NCBI