CHAC1 - ChaC glutathione specific gamma-glutamylcyclotransferase 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79094

About CHAC1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,953,471-40,956,512 (from NCBI)

This gene has 3 transcripts (splice variants), 262 orthologues and 1 paralogue. Broad expression in esophagus (RPKM 2.7), pancreas (RPKM 2.0) and 19 other tissues.

Summary

This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of Cancer recurrence among breast and ovarian Cancer patients. [provided by RefSeq, Sep 2016]

CHAC1 Products (2)

mRNA Protein Name
NM_001142776.4 NP_001136248.2 glutathione-specific gamma-glutamylcyclotransferase 1 isoform b
NM_024111.6 NP_077016.3 glutathione-specific gamma-glutamylcyclotransferase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione specific gamma-glutamylcyclotransferase activity IDA
IDA: Inferred from direct assay
27913623 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
19109178 GOA
involved in negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
22445366 GOA
involved in negative regulation of protein processing IMP
IMP: Inferred from mutant phenotype
22445366 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
19109178 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHAC1 Protein Structure

ChaC

ChaC: ChaC-like protein (75 - 248)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

glutathione-specific gamma-glutamylcyclotransferase 1

  • ChaC, cation transport regulator homolog 1

CHAC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHAC1 Q9BUX1 RHOXF2 Homo sapiens Q9BQY4
Y2H Pooling
16189514
Intra
CHAC1 Q9BUX1 RHOXF2 Homo sapiens Q9BQY4
Pull Down
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ovarian Embryonal Carcinoma

  • Embryonal Carcinoma Of Ovary

  • Embryonal Carcinoma Of The Ovary
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6929 Angelic acid 99.20% Unkown
HY-RS02590 CHAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P2060 CGP 44099 Inhibitor / Unkown
HY-RS20883 Chac1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27400 Chac1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CHAC1 VGNC VGNC:71125
Rattus norvegicus CHAC1 RGD RGD:1307153
Mus musculus CHAC1 MGD MGI:1916315
Felis catus CHAC1 VGNC VGNC:60832
Bos taurus CHAC1 VGNC VGNC:27262
Others CHAC1 NCBI