VEPH1 - ventricular zone expressed PH domain containing 1 Gene

Also Known as MELT; VEPH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79674

About VEPH1

Cytogenetic location: 3q25.31-q25.32 Genomic coordinates (GRCh38): 3:157,259,742-157,503,605 (from NCBI)

This gene has 19 transcripts (splice variants) and 200 orthologues. Biased expression in lung (RPKM 12.0), adrenal (RPKM 8.2) and 8 other tissues.

Summary

Predicted to enable phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

VEPH1 Products (6)

mRNA Protein Name
NM_001167911.2 NP_001161383.1 ventricular zone-expressed PH domain-containing protein homolog 1 isoform 2
NM_001167912.2 NP_001161384.1 ventricular zone-expressed PH domain-containing protein homolog 1 isoform 1
NM_001167915.3 NP_001161387.1 ventricular zone-expressed PH domain-containing protein homolog 1 isoform 3
NM_001167916.3 NP_001161388.1 ventricular zone-expressed PH domain-containing protein homolog 1 isoform 3
NM_001167917.1 NP_001161389.1 ventricular zone-expressed PH domain-containing protein homolog 1 isoform 5
NM_024621.2 NP_078897.2 ventricular zone-expressed PH domain-containing protein homolog 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30126976 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
26039994 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
26039994 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VEPH1 Protein Structure

PH

PH: PH domain (719 - 816)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
Protein Preferred Names Protein Names

ventricular zone-expressed PH domain-containing protein homolog 1

  • protein melted

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15640 VEPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21804 Veph1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28320 Veph1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus VEPH1 VGNC VGNC:66939
Canis familiaris VEPH1 VGNC VGNC:48255
Mus musculus VEPH1 MGD MGI:1920039
Bos taurus VEPH1 VGNC VGNC:36787
Macaca mulatta VEPH1 VGNC VGNC:79535
Rattus norvegicus VEPH1 RGD RGD:1308217
Others VEPH1 NCBI