ORAI2 - ORAI calcium release-activated calcium modulator 2 Gene

Also Known as CBCIP2; C7orf19; MEM142B; TMEM142B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80228

About ORAI2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,433,575-102,456,825 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 2 paralogues. Broad expression in spleen (RPKM 5.4), bone marrow (RPKM 5.3) and 23 other tissues.

Summary

Predicted to enable store-operated Calcium Channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in growth cone. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ORAI2 Products (4)

mRNA	Protein	Name
NM_001126340.3	NP_001119812.1	protein orai-2 isoform a
NM_001271818.2	NP_001258747.1	protein orai-2 isoform a
NM_001271819.2	NP_001258748.1	protein orai-2 isoform b
NM_032831.4	NP_116220.1	protein orai-2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17442569	GOA
enables store-operated calcium channel activity	IDA IDA: Inferred from direct assay	17442569	GOA
enables store-operated calcium channel activity	IMP IMP: Inferred from mutant phenotype	32415068	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in store-operated calcium entry	IDA IDA: Inferred from direct assay	19182790	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	32415068	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORAI2 Protein Structure

Orai-1

0
100
200
254 a.a.

Protein Preferred Names	Protein Names
protein orai-2	CAP-binding protein complex interacting protein 2

Related Diseases

Diseases	Alias
Immunodeficiency 10	Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2 Combined Immunodeficiency Due To Stim1 Deficiency IMD10 Stim1 Deficiency Cid Due To Stim1 Deficiency Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2 Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Stormorken Syndrome	Thrombocytopathy, Asplenia, And Miosis Stormorken-Sjaastad-Langslet Syndrome STRMK York Platelet Syndrome Yps Thrombocytopathy, Asplenia And Miosis Thrombocytopathy Asplenia Miosis Thrombocytopathy-Asplenia-Miosis Syndrome Miosis Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101942	Zegocractin	Inhibitor	99.96%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09823	ORAI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22702	Orai2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29216	Orai2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ORAI2	MGD	MGI:2443195
Felis catus	ORAI2	VGNC	VGNC:63972
Macaca mulatta	ORAI2	VGNC	VGNC:75665
Rattus norvegicus	ORAI2	RGD	RGD:1310213
Canis familiaris	ORAI2	VGNC	VGNC:44138
Bos taurus	ORAI2	VGNC	VGNC:32444
Others	ORAI2	NCBI