ITPKC - inositol-trisphosphate 3-kinase C Gene

Also Known as IP3KC; IP3-3KC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80271

About ITPKC

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,717,112-40,740,860 (from NCBI)

This gene has 5 transcripts (splice variants), 240 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 36.2), gall bladder (RPKM 17.5) and 24 other tissues.

Summary

This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of Enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]

ITPKC Products (2)

mRNA Protein Name
NM_001411098.1 NP_001398027.1 inositol-trisphosphate 3-kinase C isoform 2
NM_025194.3 NP_079470.1 inositol-trisphosphate 3-kinase C isoform 1

ITPKC Protein Structure

IPK

IPK: Inositol polyphosphate kinase (468 - 677)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

inositol-trisphosphate 3-kinase C

  • IP3 3-kinase C

Related Diseases

Diseases Alias
Kawasaki Disease

  • Mucocutaneous Lymph Node Syndrome

  • Acute Febrile Mucocutaneous Lymph Node Syndrome

  • Kawasaki Syndrome

  • Kd

  • Infantile Polyarteritis

  • Kawasaki Disease, Susceptibility To

  • Acute Febrile Mcls

  • Kawasaki'S Disease

  • Mlns

  • KWD
Bacterial Conjunctivitis

  • Purulent Conjunctivitis

  • Conjunctivitis, Bacterial
Heart Aneurysm

  • Cardiac Aneurysm
Coronary Aneurysm

  • Aneurysm Of Coronary Vessels

  • Aneurysmal Lesion Of Coronary Artery

  • Arteriovenous Aneurysm Of Coronary Vessels
Hydrops Of Gallbladder

  • Gallbladder Hydrops
Lymph Node Disease

  • Abnormality Of The Lymph Nodes

  • Disorder Of Lymph Node
Scarlet Fever

  • Scarlatina

  • Scarlatina Nos
Lymphadenitis

  • Acute Lymphadenitis

  • Chronic Lymphadenitis

  • Adenitis

  • Chronic Adenitis

  • Acute Adenitis

  • Inflammation Of Lymph Node

  • Adenitis Nos

  • Inflammation Of Gland

  • Lymphatic Gland Inflammation

  • Lymph Gland Inflammation

  • Polyadenitis

  • Chronic Adenitis Of Any Lymph Node Except Mesenteric

  • Chronic Lymphadenitis Except Mesenteric

  • Chronic Non-Specific Lymphadenitis
Cervical Adenitis

  • Cervical Lymphadenitis
Pyuria

  • Pus Cells In Urine
Reye Syndrome

  • Reye'S Syndrome

  • Rasmussen Encephalitis

  • Fatty Liver With Encephalopathy

  • Rasmussen'S Encephalitis

  • Re

  • Rs

  • Rasmussen Syndrome

  • Liver Fatty Metamorphosis--Acute Encephalopathy Syndrome

  • Reye Encephalopathy
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Autoimmune Vasculitis
Conjunctival Disease

  • Conjunctival Diseases

  • Conjunctival Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126750 GNF362 Inhibitor 99.86% Unkown
HY-RS06990 ITPKC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22580 Itpkc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29098 Itpkc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ITPKC MGD MGI:2442554
Canis familiaris ITPKC VGNC VGNC:42156
Felis catus ITPKC VGNC VGNC:62986
Macaca mulatta ITPKC VGNC VGNC:73599
Rattus norvegicus ITPKC RGD RGD:631336
Bos taurus ITPKC VGNC VGNC:30345
Others ITPKC NCBI