ITPKC - inositol-trisphosphate 3-kinase C Gene

Homo sapiens

Also known as IP3KC; IP3-3KC

Gene ID: 80271 | Gene type: protein coding

About ITPKC

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,717,112-40,740,860 (from NCBI)

This gene has 5 transcripts (splice variants), 240 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 36.2), gall bladder (RPKM 17.5) and 24 other tissues.

Summary

This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]

ITPKC Products(2)

mRNA	Protein	Name
NM_001411098.1	NP_001398027.1	inositol-trisphosphate 3-kinase C isoform 2
NM_025194.3	NP_079470.1	inositol-trisphosphate 3-kinase C isoform 1

ITPKC Protein Structure

IPK

0
200
400
600
683 a.a.

Protein Preferred Names

Protein Names

inositol-trisphosphate 3-kinase C

IP3 3-kinase C

Related Diseases

Diseases

Alias

Kawasaki Disease

Mucocutaneous Lymph Node Syndrome	Acute Febrile Mucocutaneous Lymph Node Syndrome
Kawasaki Syndrome	Kd
Infantile Polyarteritis	Kawasaki Disease, Susceptibility To
Acute Febrile Mcls	Kawasaki'S Disease
Mlns	KWD

Bacterial Conjunctivitis

Purulent Conjunctivitis

Conjunctivitis, Bacterial

Heart Aneurysm

Cardiac Aneurysm

Coronary Aneurysm

Aneurysm Of Coronary Vessels	Aneurysmal Lesion Of Coronary Artery
Arteriovenous Aneurysm Of Coronary Vessels

Hydrops Of Gallbladder

Gallbladder Hydrops

Lymph Node Disease

Abnormality Of The Lymph Nodes

Disorder Of Lymph Node

Scarlet Fever

Scarlatina

Scarlatina Nos

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Adenitis	Chronic Adenitis
Acute Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Cervical Adenitis

Cervical Lymphadenitis

Pyuria

Pus Cells In Urine

Reye Syndrome

Reye'S Syndrome	Rasmussen Encephalitis
Fatty Liver With Encephalopathy	Rasmussen'S Encephalitis
Re	Rs
Rasmussen Syndrome	Liver Fatty Metamorphosis--Acute Encephalopathy Syndrome
Reye Encephalopathy

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Autoimmune Vasculitis

Conjunctival Disease

Conjunctival Diseases

Conjunctival Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126750	GNF362	Inhibitor	99.63%	Unkown
HY-RS06990	ITPKC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ITPKC	MGD	MGI:2442554
Canis familiaris	ITPKC	VGNC	VGNC:42156
Felis catus	ITPKC	VGNC	VGNC:62986
Macaca mulatta	ITPKC	VGNC	VGNC:73599
Rattus norvegicus	ITPKC	RGD	RGD:631336
Bos taurus	ITPKC	VGNC	VGNC:30345

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