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SCUBE1 - signal peptide, CUB domain and EGF like domain containing 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80274

About SCUBE1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,197,280-43,343,372 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues and 2 paralogues. Broad expression in ovary (RPKM 8.0), testis (RPKM 5.9) and 17 other tissues.

Summary

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

SCUBE1 Products (1)

mRNA	Protein	Name
NM_173050.5	NP_766638.2	signal peptide, CUB and EGF-like domain-containing protein 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	12270931	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12270931	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12270931	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	12270931	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12270931	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	12270931	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12270931	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCUBE1 Protein Structure

EGF_3

cEGF

FXa_inhibition

EGF_CA

Ephrin_rec_like

CUB

0
200
400
600
800
988 a.a.

Protein Preferred Names	Protein Names
signal peptide, CUB and EGF-like domain-containing protein 1	signal peptide, CUB domain, EGF-like 1

Related Diseases

Diseases	Alias
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Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	Star Syndrome Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome Syndactyly With Renal And Anogenital Malformations STAR Syndactyly, Telecanthus, Anogenital And Renal Malformations Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12571	SCUBE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCUBE1	RGD	RGD:1309015
Bos taurus	SCUBE1	VGNC	VGNC:34371
Canis familiaris	SCUBE1	VGNC	VGNC:45935
Macaca mulatta	SCUBE1	VGNC	VGNC:77008
Mus musculus	SCUBE1	MGD	MGI:1890616
Others	SCUBE1	NCBI