1. Gene
  2. ADAM12 - ADAM metallopeptidase domain 12 Gene

ADAM12 - ADAM metallopeptidase domain 12 Gene

Homo sapiens

Also known as MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1

Gene ID: 8038 | Gene type: protein coding

About ADAM12

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:126,012,391-126,388,477 (from NCBI)

This gene has 7 transcripts (splice variants), 267 orthologues and 20 paralogues. Biased expression in placenta (RPKM 63.0), gall bladder (RPKM 5.5) and 2 other tissues.

Summary

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

ADAM12 Products(5)

mRNA Protein Name
NM_001288973.2 NP_001275902.1 disintegrin and metalloproteinase domain-containing protein 12 isoform 3 preproprotein
NM_001288974.2 NP_001275903.1 disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein
NM_001288975.2 NP_001275904.1 disintegrin and metalloproteinase domain-containing protein 12 isoform 5 preproprotein
NM_003474.6 NP_003465.3 disintegrin and metalloproteinase domain-containing protein 12 isoform 1 preproprotein
NM_021641.5 NP_067673.2 disintegrin and metalloproteinase domain-containing protein 12 isoform 2 preproprotein

ADAM12 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (60 - 162)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (214 - 416)

Disintegrin

Disintegrin: Disintegrin (433 - 507)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (510 - 632)

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  • 909 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 12

meltrin-alpha

Recombinant ADAM12 Proteins

Cat. No. Product Name Accession Purity
HY-P72814 ADAM12 Protein, Human (HEK293, His) O43184 (R29-S513) ≥95%

Related Diseases

Diseases Alias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Benign Giant Cell Tumor

Giant Cell Tumors

Prostate Signet Ring Cell Adenocarcinoma

Prostate Signet Ring Cell Carcinoma

Signet Ring Cell Carcinoma Of Prostate

Acinar Prostate Adenocarcinoma, Signet Ring Variant

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADAM12 VGNC VGNC:69469
Felis catus ADAM12 VGNC VGNC:59575
Bos taurus ADAM12 VGNC VGNC:25605
Rattus norvegicus ADAM12 RGD RGD:1583652
Canis familiaris ADAM12 VGNC VGNC:37574
Mus musculus ADAM12 MGD MGI:105378
Others ADAM12 NCBI