INHBE - inhibin subunit beta E Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83729

About INHBE

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,455,307-57,458,025 (from NCBI)

This gene has 4 transcripts (splice variants), 92 orthologues and 31 paralogues. Restricted expression toward liver (RPKM 43.7).

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, Apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]

INHBE Products (1)

mRNA Protein Name
NM_031479.5 NP_113667.1 inhibin beta E chain preproprotein

INHBE Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (32 - 221)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (246 - 350)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

inhibin beta E chain

  • activin beta-E chain

Recombinant INHBE Proteins

Cat. No. Product Name Accession Purity
HY-P75888 INHBE Protein, Human (HEK293, Fc) P58166 (T237-S350) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Liver Benign Neoplasm

  • Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06816 INHBE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17982 Inhbe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24453 Inhbe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus INHBE MGD MGI:109269
Felis catus INHBE VGNC VGNC:62924
Bos taurus INHBE VGNC VGNC:30203
Canis familiaris INHBE VGNC VGNC:54315
Rattus norvegicus INHBE RGD RGD:621196
Others INHBE NCBI