NTPCR - nucleoside-triphosphatase, cancer-related Gene

Also Known as THEP1; C1orf57; HCR-NTPase

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84284

About NTPCR

This gene has 8 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 18.5), kidney (RPKM 18.3) and 25 other tissues.

Summary

The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]

NTPCR Products (3)

mRNA Protein Name
NM_001329452.2 NP_001316381.1 cancer-related nucleoside-triphosphatase isoform 2
NM_001329453.2 NP_001316382.1 cancer-related nucleoside-triphosphatase isoform 3
NM_032324.3 NP_115700.1 cancer-related nucleoside-triphosphatase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ribonucleoside triphosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
17291528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTPCR Protein Structure

NTPase_1

NTPase_1: NTPase (4 - 181)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

cancer-related nucleoside-triphosphatase

  • human cancer-related NTPase

NTPCR Antibodies

Cat. No. Product Name Application Reactivity
HY-P81699 NTPCR Antibody (YA1444) WB, IP Human

Related Diseases

Diseases Alias
Blackwater Fever

  • Black Water Fever

  • Hemoglobinuric, Malaria

  • Malarial Hemoglobinuria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09627 NTPCR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NTPCR RGD RGD:1306192
Mus musculus NTPCR MGD MGI:1913816