NT5C1A - 5'-nucleotidase, cytosolic IA Gene

Also Known as CN1; CNI; CN-I; CN1A; CN-IA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84618

About NT5C1A

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,651,229-39,672,107 (from NCBI)

This gene has 1 transcript (splice variant), 269 orthologues and 1 paralogue. Biased expression in heart (RPKM 3.5), brain (RPKM 1.5) and 5 other tissues.

Summary

Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]

NT5C1A Products (1)

mRNA Protein Name
NM_032526.3 NP_115915.1 cytosolic 5'-nucleotidase 1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-nucleotidase activity IDA
IDA: Inferred from direct assay
599155 GOA
enables IMP 5'-nucleotidase activity IDA
IDA: Inferred from direct assay
11133996 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
8967393 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in AMP catabolic process IDA
IDA: Inferred from direct assay
11133996 GOA
involved in IMP catabolic process IDA
IDA: Inferred from direct assay
11133996 GOA
involved in allantoin metabolic process IDA
IDA: Inferred from direct assay
11133996 GOA
involved in dAMP catabolic process IDA
IDA: Inferred from direct assay
11133996 GOA
involved in dGMP catabolic process IDA
IDA: Inferred from direct assay
11133996 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
11133996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NT5C1A Protein Structure

5-nucleotidase

5-nucleotidase: 5'-nucleotidase (81 - 353)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
Protein Preferred Names Protein Names

cytosolic 5'-nucleotidase 1A

  • AMP-specific 5'-NT

NT5C1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NT5C1A Q9BXI3 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
Intra
NT5C1A Q9BXI3 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Granulomatous Myositis
Myositis

  • Idiopathic Inflammatory Myopathy

  • Idiopathic Inflammatory Myositis

  • Iim

  • Imm

  • Idiopathic Inflammatory Myopathies

  • Myopathy, Familial Idiopathic Inflammatory

  • Inflammatory Disorder Of Muscle

  • Idiopathic Inflammatory Myopathy, Familial

  • Inflammatory Myopathy, Idiopathic

  • Myopathies Idiopathic Inflammatory

  • Familial Idiopathic Inflammatory Myopathy
Anal Canal Adenocarcinoma

  • Adenocarcinoma Of The Anal Canal

  • Adenocarcinoma Of Anal Canal
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2

  • Ibmpfd2

  • Msp2

  • Multisystem Proteinopathy 2
Crigler-Najjar Syndrome, Type I

  • Crigler-Najjar Syndrome

  • Crigler-Najjar Syndrome Type 1

  • Bilirubin Udp Glucuronyl Transferase Deficiency

  • Crigler Najjar Syndrome

  • Crigler Najjar Syndrome, Type 1

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

  • Bilirubin-Ugt Deficiency

  • Hyperbilirubinemia, Crigler-Najjar Type I

  • Hblrcn1

  • Familial Nonhemolytic Unconjugated Hyperbilirubinemia

  • Hereditary Unconjugated Hyperbilirubinemia

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

  • Bilirubin-Ugt Deficiency Type 1

  • Crigler-Najjar Syndrome 1

  • CN1

  • Cn-I

  • Crigler-Najjar Syndrome Type I

  • Hereditary Unconjugated Hyperbilirubinaemia

  • Ugt Deficiency

  • Bilirubin Glucuronosyltransferase Deficiency

  • Crigler-Najjar Disease Or Syndrome

  • Deficiency Of Glucuronosyltransferase

  • Glucuronyl Transferase Deficiency

  • Glucuronyltransferase Deficiency

  • Udp Glucuronyl Transferase Deficiency

  • Cns - [Crigler-Najjar Syndrome]

  • Congenital Familial Nonhemolytic Jaundice
Antisynthetase Syndrome

  • As Syndrome

  • Anti-Jo1 Syndrome
Kernicterus

  • Bilirubin Encephalopathy

  • Hyperbilirubinemic Encephalopathy

  • Kernicterus Spectrum Disorder
Childhood Type Dermatomyositis

  • Juvenile Dermatomyositis

  • Juvenile Dm

  • Childhood Dermatomyositis

  • Amyopathic Dermatomyositis

  • Adm

  • Dermatomyositis Sine Myositis

  • Dermatomyositis, Childhood Type
Postpoliomyelitis Syndrome

  • Postpolio Syndrome

  • Post-Polio Syndrome

  • Post Polio Syndrome

  • Polio Late Effects

  • Post-Polio Muscular Atrophy

  • Post-Polio Sequelae

  • Post-Poliomyelitic Syndrome

  • Postpolio Sequelae

  • Postpoliomyelitic Syndrome

  • Postpoliomyelitis Sequelae
Adult Dermatomyositis

  • Adult Onset Dermatomyositis

  • Adult Type Dermatomyositis
Gilbert Syndrome

  • Gilbert Disease

  • Gilbert'S Disease

  • Gilbert'S Syndrome

  • Cholemia, Familial

  • Familial Nonhemolytic Jaundice

  • Meulengracht Syndrome

  • Gilbert Syndrome, Susceptibility To

  • Hyperbilirubinemia, Gilbert Type

  • Hblrg

  • Hyperbilirubinemia, Arias Type

  • Hyperbilirubinemia I

  • Constitutional Hyperbilirubinemia

  • Gilbert-Meulengracht Syndrome

  • Hereditary Nonhemolytic Jaundice

  • Hyperbilirubinemia Arias Type

  • Hyperbilirubinemia Type 1

  • Constitutional Liver Dysfunction

  • Gilbert-Lereboullet Syndrome

  • Hyperbilirubinemia 1

  • Unconjugated Benign Bilirubinemia

  • GILBS

  • Gilberts Syndrome

  • Familial Nonhaemolytic Jaundice

  • Constitutional Hyperbilirubinaemia

  • Hereditary Nonhaemolytic Bilirubinaemia

  • Familial Nonhaemolytic Bilirubinaemia

  • Idiopathic Hyperbilirubinaemia

  • Icterus Intermittens Juvenilis

  • Chronic Intermittent Juvenile Jaundice

  • Low-Grade Chronic Hyperbilirubinaemia Syndrome

  • Benign Unconjugated Bilirubinaemia Syndrome

  • Hereditary Nonhaemolytic Jaundice

  • Idiopathic Unconjugated Hyperbilirubinaemia

  • Gilbert--Lereboullet Syndrome

  • Constitutional Hepatic Dysfunction

  • Meulengracht Icterus

  • Cholaemia Familiaris Simplex

  • Familial Cholaemia

  • Congenital Familial Cholaemia

  • Physiologic Cholaemia

  • Hyperbilirubinaemia Type 1

  • Gilbert Cholaemia
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09608 NT5C1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19266 Nt5c1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25755 Nt5c1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NT5C1A VGNC VGNC:32290
Rattus norvegicus NT5C1A RGD RGD:1310908
Macaca mulatta NT5C1A VGNC VGNC:106419
Felis catus NT5C1A VGNC VGNC:63897
Mus musculus NT5C1A MGD MGI:2155700
Canis familiaris NT5C1A VGNC VGNC:43995
Others NT5C1A NCBI