CNDP1 - carnosine dipeptidase 1 Gene

Also Known as CN1; CPGL2; HsT2308

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84735

About CNDP1

Cytogenetic location: 18q22.3 Genomic coordinates (GRCh38): 18:74,534,500-74,587,212 (from NCBI)

This gene has 7 transcripts (splice variants), 139 orthologues and 3 paralogues. Biased expression in brain (RPKM 44.8), liver (RPKM 24.2) and 1 other tissue.

Summary

This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]

CNDP1 Products (1)

mRNA Protein Name
NM_032649.6 NP_116038.4 beta-Ala-His dipeptidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dipeptidase activity IDA
IDA: Inferred from direct assay
24891507 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
24891507 GOA
acts upstream of or within regulation of protein metabolic process IDA
IDA: Inferred from direct assay
24891507 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
24891507 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNDP1 Protein Structure

Peptidase_M20

Peptidase_M20: Peptidase family M20/M25/M40 (128 - 500)

M20_dimer

M20_dimer: Peptidase dimerisation domain (242 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 507 a.a.
Protein Preferred Names Protein Names

beta-Ala-His dipeptidase

  • CNDP dipeptidase 1

CNDP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNDP1 Q96KN2 CNDP2 Homo sapiens Q96KP4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CNDP1 Proteins

Cat. No. Product Name Accession Purity
HY-P7740 Carnosine Dipeptidase 1/CNDP1 Protein, Human (HEK293, His) Q96KN2 (S27-L506) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Homocarnosinosis

  • Homocarnosinase Deficiency

  • Hereditary Spastic Paraplegia Mental Impairment And Thin Corpus Callosum

  • Spastic Paraplegia 11

  • Autosomal Recessive Spastic Paraplegia Type 11

  • Hereditary Spastic Paraplegia 11

  • Nakamura Osame Syndrome

  • Spg11

  • Spastic Paraplegia - Intellectual Deficit - Thin Corpus Callosum

  • Serum Carnosinase Deficiency
Gamma-Amino Butyric Acid Metabolism Disorder

  • Disorder Of Gamma-Aminobutyric Acid Metabolism

  • Disorder Of Gaba Metabolism

  • Disorders Of Gaba - [Gamma Aminobutyric Acid] Metabolism
Microvascular Complications Of Diabetes 3

  • Diabetic Nephropathy

  • Microvascular Complications Of Diabetes, Susceptibility To, 3

  • MVCD3

  • Nephropathy, Diabetic

  • Nephropathy, Diabetic, Susceptibility To

  • End-Stage Renal Disease, Diabetic

  • End-Stage Renal Disease, Diabetic, Susceptibility To

  • Diabetic End-Stage Renal Disease

  • Diabetic Nephropathies
Hypotrichosis 4

  • HYPT4

  • Marie Unna Hereditary Hypotrichosis 1

  • Muhh1

  • Hypotrichosis, Marie Unna Type, 1

  • Hypotrichosis Marie Unna 1

  • Marie Unna Hereditary Hypotrichosis Type 1

  • Hypotrichosis, Hereditary, Marie Unna Type, 1

  • Hypotrichosis, Type 4
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02876 CNDP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20383 Cndp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26893 Cndp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CNDP1 MGD MGI:2451097
Felis catus CNDP1 VGNC VGNC:61008
Bos taurus CNDP1 VGNC VGNC:27493
Canis familiaris CNDP1 VGNC VGNC:39391
Rattus norvegicus CNDP1 RGD RGD:1359493
Macaca mulatta CNDP1 VGNC VGNC:71257
Others CNDP1 NCBI