MAEL - maelstrom spermatogenic transposon silencer Gene
Also Known as CT128; SPATA35
Species: Homo sapiens
About MAEL
This gene has 6 transcripts (splice variants) and 130 orthologues. Restricted expression toward testis (RPKM 61.7).
Summary
Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in gamete generation; negative regulation of macromolecule metabolic process; and piRNA metabolic process. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule metabolic process. Predicted to be located in piP-body. Predicted to be active in P granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
MAEL Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001286377.2 | NP_001273306.1 | protein maelstrom homolog isoform 2 |
| NM_001286378.2 | NP_001273307.1 | protein maelstrom homolog isoform 3 |
| NM_032858.3 | NP_116247.1 | protein maelstrom homolog isoform 1 |
MAEL Protein Structure
HMG_box_2: HMG-box domain (2 - 70)
Maelstrom: piRNA pathway germ-plasm component (130 - 326)
- 0
- 100
- 200
- 300
- 400
- 434 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein maelstrom homolog |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Astigmatism |
|
|
| Spermatogenic Failure |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS07955 | MAEL Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS21370 | Mael Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS27889 | Mael Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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