ADAM23 - ADAM metallopeptidase domain 23 Gene

Homo sapiens

Also known as MDC3; MDC-3

Gene ID: 8745 | Gene type: protein coding

About ADAM23

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:206,443,532-206,621,127 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 20 paralogues. Biased expression in brain (RPKM 14.8), heart (RPKM 6.7) and 6 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]

ADAM23 Products(2)

mRNA	Protein	Name
NM_001410985.1	NP_001397914.1	disintegrin and metalloproteinase domain-containing protein 23 isoform 2 preproprotein
NM_003812.4	NP_003803.1	disintegrin and metalloproteinase domain-containing protein 23 isoform 1 preproprotein

ADAM23 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
832 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 23

metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

Recombinant ADAM23 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79163	ADAM23 Protein, Human (CHO, His)	O75077 (S60-H585)	≥95%

Related Diseases

Diseases

Alias

Epilepsy, Familial Temporal Lobe, 1

ETL1	Adpeaf
Adlte	Epilepsy, Partial, With Auditory Features
Autosomal Dominant Partial Epilepsy With Auditory Features	Epilepsy, Lateral Temporal Lobe, Autosomal Dominant
Familial Temporal Lobe Epilepsy 1	Partial Epilepsy With Auditory Features
Autosomal Dominant Lateral Temporal Lobe Epilepsy	Lateral Temporal Lobe Epilepsy Autosomal Dominant
Epilepsy, Temporal Lobe, Familial, Type 1

Limbic Encephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00279	ADAM23 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADAM23	VGNC	VGNC:25609
Canis familiaris	ADAM23	VGNC	VGNC:37581
Macaca mulatta	ADAM23	VGNC	VGNC:69484
Rattus norvegicus	ADAM23	RGD	RGD:1305739
Felis catus	ADAM23	VGNC	VGNC:59581
Mus musculus	ADAM23	MGD	MGI:1345162
Others	ADAM23	NCBI

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