ADAM23 - ADAM metallopeptidase domain 23 Gene

Also Known as MDC3; MDC-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8745

About ADAM23

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:206,443,532-206,621,127 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 20 paralogues. Biased expression in brain (RPKM 14.8), heart (RPKM 6.7) and 6 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]

ADAM23 Products (2)

mRNA Protein Name
NM_001410985.1 NP_001397914.1 disintegrin and metalloproteinase domain-containing protein 23 isoform 2 preproprotein
NM_003812.4 NP_003803.1 disintegrin and metalloproteinase domain-containing protein 23 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20463223 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM23 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (130 - 249)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (299 - 496)

Disintegrin

Disintegrin: Disintegrin (511 - 585)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (588 - 708)

  • 0
  • 200
  • 400
  • 600
  • 832 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 23

  • metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

Related Diseases

Diseases Alias
Epilepsy, Familial Temporal Lobe, 1

  • ETL1

  • Adpeaf

  • Adlte

  • Epilepsy, Partial, With Auditory Features

  • Autosomal Dominant Partial Epilepsy With Auditory Features

  • Epilepsy, Lateral Temporal Lobe, Autosomal Dominant

  • Familial Temporal Lobe Epilepsy 1

  • Partial Epilepsy With Auditory Features

  • Autosomal Dominant Lateral Temporal Lobe Epilepsy

  • Lateral Temporal Lobe Epilepsy Autosomal Dominant

  • Epilepsy, Temporal Lobe, Familial, Type 1
Limbic Encephalitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00279 ADAM23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19761 Adam23 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26258 Adam23 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADAM23 VGNC VGNC:25609
Canis familiaris ADAM23 VGNC VGNC:37581
Macaca mulatta ADAM23 VGNC VGNC:69484
Rattus norvegicus ADAM23 RGD RGD:1305739
Felis catus ADAM23 VGNC VGNC:59581
Mus musculus ADAM23 MGD MGI:1345162
Others ADAM23 NCBI